胃食管反流病的抑酸治疗对肠道微生态影响的观察  

Impact of acid inhibitor treatment on the intestinal microecology in gastroesophageal reflux disease

作　　者：金建军[1] 赵晓[1] 张世同[1] 张英剑[1] 郑玉峰[1] 白艳丽[1] 赵双琴[1] 

机构地区：[1]河南科技大学第一附属医院消化内科,河南471003

出　　处：《世界感染杂志》2011年第1期41-42,57,共3页World Journal of Infection

摘　　要：目的观察长期抑酸治疗能否对肠道微生态环境造成影响。方法对120例胃食管反流病人分别在治疗开始前、治疗1mo、治疗3mo检测呼气氢浓度，判断呼气氢试验的阳性率和腹胀、腹痛、纳差、腹泻的发生率。结果在用质子泵抑制剂治疗前，呼气氢试验的阳性率、腹胀、腹痛、纳差、腹泻的发生率和对照组相比无显著性差别；治疗1mo后及治疗3mo后即明显高于对照组和治疗前，并且治疗3mo又明显高于治疗1mo，有显著的统计学差异。结论强而持久的抑制胃酸可能对肠道微生态环境及消化功能造成影响，并且时间越长影响越明显。Objective To observe if treatment by acid inhibitor impacts the intestinal microecology in gastroesophageal reflux disease. Methods Breath hydrogen density of 120 patients with gastroesophageal reflux disease was detected before therapy, 1 month after therapy, 3 month after therapy and judge the positive incidence of Breath hydrogen test and incidence of abdominal distention, stomachache, poor appetite, diarrhea. Results the positive incidence of Breath hydrogen test and incidence of abdominal distention, stomachache, poor appetite before therapy with proton pump inhibitor are not higher compared with control group, are significantly lower than that in I month after therapy, 3 month after therapy. The positive incidence of breath hydrogen test and incidence of abdominal distention, stomachache, poor appetite in 3 month after therapy are significantly higher than that in t month after therapy. Conclusions It may impact intestinal microecology and digestive function to treat by acid inhibitor for long time. The longer you used, the greater it impacted.

关 键 词：胃食管反流病 质子泵抑制剂 肠道微生态环境 

分 类 号：R571[医药卫生—消化系统]