肾癌及膀胱癌患者检测外周血可溶性白介素2受体水平的意义  

Significance of sIL-2R level of peripheral blood in patients with renal or bladder cancer

作　　者：王禾[1] 刘悦[1] 刘佃成[1] 汤群辉[1] 辛建国[1] 于茂生[1] 

机构地区：[1]第四军医大学西京医院泌尿外科,陕西西安710033

出　　处：《第四军医大学学报》1999年第10期902-903,共2页Journal of the Fourth Military Medical University

摘　　要：目的： 探讨肾癌及膀胱癌患者外周血中可溶性白细胞介素２受体（ｓＩＬ－２Ｒ）表达及意义． 方法： 采用ＥＬＩＳＡ 双抗体夹心法检测２４例膀胱癌、１５例肾癌，２０例正常对照外周血中ｓＩＬ－２Ｒ水平． 结果： 肿瘤患者ｓＩＬ－２Ｒ水平显著高于正常（Ｐ＜ ０．００１）． 虽然所有肿瘤患者ｓＩＬ－２Ｒ水平均升高，但其中肿瘤小、病理级别低者，ｓＩＬ－２Ｒ水平表现较低的趋势． 结论： 血清ｓＩＬ－２Ｒ能够反映机体抗肿瘤细胞免疫活性水平的高低；测定血清ｓＩＬ－２Ｒ水平可监测早期复发的肿瘤，并可作为肾癌、膀胱癌患者病期及预后判断的重要指标．AIM: To study the expression and significance of the soluble interleukin 2 receptor (sIL 2R) in the peripheral blood of patients with bladder cancers or renal cancers. METHODS: By Double Sandwich ELISA method, the levels of the sIL 2R were evaluated in the peripheral blood of 24 patients with bladder cancer, 15 patients with renal cancer and 20 normal controls. RESULTS: In the cancer patients, the levels of sIL 2R were higher as compared with those of the normal and negative controls ( P <0.001), but they were not as high as those in the positive controls. Although this increase was observed in all the stages of the disease, a trend of lower levels of sIL 2R was found in patients with tumors of smaller size and lower degree. CONCLUSION: As sIL 2R can reflect the status of anti tumor immunity, evaluation of sIL 2R in the peripheral blood levels may serve as a useful marker for the early relapsing carcinoma and an assessment of the biological behaviors of renal and bladder cancers.

关 键 词：肾癌 膀胱癌 外周血 SIL-2R ELISA 

分 类 号：R737.190.4[医药卫生—肿瘤] R737.140.4[医药卫生—临床医学]