不明原因反复自然流产患者的抗生殖免疫抗体分析  

Analysis of Anti-reproductive Antibodies of Recurrent Spontaneous Abortion of Unknown Etiology

作　　者：李素萍[1] 金玉霞[1] 苗正友[1] 

机构地区：[1]嘉兴市妇幼保健院产前诊断中心,浙江嘉兴340000

出　　处：《中国现代医生》2011年第10期134-135,共2页China Modern Doctor

摘　　要：目的通过对不明原因的反复自然流产患者进行抗心磷脂抗体和抗子宫内膜抗体的检测,分析不明原因反复自然流产与抗生殖免疫抗体的关系。方法 312例不明原因反复自然流产患者为流产组,100例健康孕妇为对照组,采用酶联免疫方法检测这两组的抗心磷脂抗体(ACAb)和抗子宫内膜抗体(EMAb)。结果流产组ACAb阳性率13.1%,EMAb阳性率11.5%;对照组ACAb阳性率4.0%,EMAb阳性率2.0%。流产组抗生殖免疫抗体阳性率均高于对照组(P<0.05)。结论不明原因反复自然流产患者体内存在生殖抗体是形成反复流产的原因之一。Objective To study the relationship between anti-reproductive antibodies and recurrent spontaneous abortion of unknown etiology. Methods ELISA was performed to determine the serum levels of ACAb and EMAb in 312 patients with recurrent spontaneous abortion of unknown etiology and 100 age-and sex-matched healthy controls. Results The positive rate of ACAb was 13.1% in patients,while it was only 4.0% in control group. The positive rate of EMAb was 11.5% in patients,while it was only 2.0% in control group,The levels of anti-reproductive antibodies were higher than that in control group（ P〈0.05 ）.The patients with recurrent spontaneous abortion of unknown have significantly higher serum levels of anti-reproductive antibodies to the control. Conclusion The presence of anti-reproductive antibodies is one of the reasons of spontaneous abortion.

关 键 词：不明原因反复自然流产 抗生殖免疫抗体 

分 类 号：R714.21[医药卫生—妇产科学]