P504S、EZH2和pim-1在前列腺癌组织中的表达和意义  

Expressions and significance of P504S, EZH2 and pim-1 in prostate cancer

作　　者：张世革[1] 邱雁[2] 邱梁[2] 吴烨[1] 丁毅[1] 

机构地区：[1]江苏省老年医院泌尿外科,南京210024 [2]江苏省老年医院病理科,南京210024

出　　处：《现代泌尿生殖肿瘤杂志》2010年第6期354-356,共3页Journal of Contemporary Urologic and Reproductive Oncology

摘　　要：目的探讨P504S、EZH2和pim-1在前列腺癌组织中的表达和意义。方法采用免疫组织化学技术检测P504S、EZH2和pim-1在前列腺癌和前列腺增生中的表达,分析其表达水平与Gleason评分的关系。结果 P504S、EZH2和pim-1在前列腺癌中均为明显高表达,其与Gleason评分的相关性分别为0.418(P<0.05)、0.268(P>0.05)和0.567(Ρ<0.01)。结论 P504S、EZH2和pim-1对前列腺癌均具有高度敏感性和特异性,其表达强度与Gleason评分存在一定的相关性,对前列腺癌的预后判断有参考价值。Objective To determine the expression of P504S, EZH2 and pim-1 in prostate cancer and its correlation with Gleason score. Methods Immunohistoehemical stain was used to study the expression of P504S,EZH2 and pim-1 in prostate cancer and benign prostate hyperplasia. Its expression level was analysed with respect to Gleason score. Results P504S, EZH2 and pim-1 was overexpressed in prostate cancer. And Gleason score was positively correlated with P504S （0.418 ,P〈0.05）, EZH2（0.268,P〈0.05） and pim- 1（0.567, P〈0.01）. Conclusions P504S, EZH2 and pim-1 are sensitive and specific marker for prostate cancer. The expression level of P5048, EZH2 and pim-1 was related to Gleason score.

关 键 词：前列腺肿瘤 P504S EZH2 pim- 1 

分 类 号：R737.25[医药卫生—肿瘤]