心复康口服液对心衰大鼠心肌乳酸的影响  

Effects of Xin Fu Kang Oral Liquid on Lactate in Rats with Congestive Heart Failure

作　　者：徐淑乐[1] 曹雪滨[1] 张刚[1] 王艳飞[1] 王洪良[1] 何建成[2] 胡元会[3] 刘伟[1] 杨麦广[1] 

机构地区：[1]解放军第252医院心内科,河北保定071000 [2]上海中医药大学基础医学院,上海201203 [3]中国中医科学院广安门医院,北京100053

出　　处：《中国中医基础医学杂志》2010年第12期1113-1115,共3页JOURNAL OF BASIC CHINESE MEDICINE

基　　金：国家自然科学基金项目(30873398)-益气温阳活血化瘀方药对心衰大鼠心肌线粒体呼吸酶活性及ND4的影响;全军"十一五"攻关资助项目(2006MA074)-益气温阳活血化瘀机理研究

摘　　要：目的:研究心复康口服液对心衰大鼠心肌乳酸水平的影响,探讨中药改善心肌能量代谢的机制。方法:将75只大鼠随机等分为假手术组(SH)、腹主动脉缩窄模型组(CAA)、心复康口服液治疗组(XFK)。建立模型并检测其心功能参数、心肌乳酸含量。结果:6周、12周时CAA组大鼠心功能明显降低,XFK组较CAA组改善(P<0.01);6周时XFK组、CAA组大鼠心肌乳酸均升高(P<0.01),12周时XFK组大鼠乳酸下降(P<0.01)。结论:心复康口服液对心衰大鼠心功能及乳酸水平有改善。Objective：To study the Effects of XinFuKang Oral Liquid on Lactate in rats of congestive heart failure and discuss the mechanisms of myocardial energy metabolism improved by Chinese herbs.Methods： 75 rats were randomly divided into Sham operation（SH）,Coarctation of abdominal aorta model group（CAA） and Xinfufang Oral Liquid group（XFK）.Then observed the parameters of cardiac function models,content of lactate.Results： Cardiac function of CAA group decreased at the 6thweek and the12th week,while the XFK group improved significantly compared with CAA group;The level of lactate increased significantly at the 6th and 12th week in CAA and XFK group（P 0.01）,and the level of lactate decreased at the 12th week in XFK group（P 0.01）.Conclusion： Xin Fu Kang Oral Liquid can obviously improve cardiac function and the level of lactate in rats of congestive heart failure.

关 键 词：心复康口服液 乳酸 充血性心力衰竭 心肌能量代谢 

分 类 号：R285.5[医药卫生—中药学]