纳米脂质体应用于肿瘤研究的进展  

Progress in the applications of nanoliposomes in cancer research

作　　者：邓启盼[1] 曹亚[1] 

机构地区：[1]中南大学肿瘤研究所,长沙410078

出　　处：《国际病理科学与临床杂志》2010年第6期489-494,共6页Journal of International Pathology and Clinical Medicine

基　　金：国家重点基础研究发展计划(2009CB522300)~~

摘　　要：纳米脂质体是一类直径大小在10至数百纳米之间的脂质体。由于其特殊的尺度范围,同时具有脂质体的生物相容性等优良特征,纳米脂质体被广泛应用于肿瘤防治的临床前研究和临床应用。本文介绍了纳米脂质体的特征以及影响其效果的因素,并对近年来将纳米脂质体作为运输载体用于改善传统化疗药物治疗效果、体内运送siRNA以及在分子影像等方面的研究进行综述。Nanoliposomes are a group of liposomes with diameters ranging from 10 to several hundred nanometers.Due to its special size range and the biocompatibility of liposome,nanoliposomes are extensively useful in the preclinical research and clinical application in treatment and prevention of cancer.In the review,we discussed the characteristic of nanoliposomes and the factors that influence their effectiveness,and summarized the progress in the application of nanoliposomes as carriers in improving therapeutic efficacy of traditional chemotherapeutics,in carrying siRNA in vivo and in the field of molecular imaging.

关 键 词：纳米脂质体 抗肿瘤药物 SIRNA 分子影像 

分 类 号：R73-3[医药卫生—肿瘤]