28例嗅神经母细胞瘤临床分析  

Clinical analysis of 28 cases of Esthesioneuroblastoma

作　　者：谭志强[1] 李友忠[1] 谢鼎华[1] 

机构地区：[1]中南大学湘雅二医院耳鼻咽喉头颈外科,湖南长沙410011

出　　处：《中国现代医学杂志》2010年第24期3778-3780,3783,共4页China Journal of Modern Medicine

摘　　要：目的探讨嗅神经母细胞瘤的治疗方式以及影响患者预后的因素。方法回顾性分析该院1986年5月-2008年12月收治28例嗅神经母细胞瘤患者的临床资料,根据Kadish分期：A期4例,B期11例,C期13例。27例患者行手术治疗,其中14例行鼻内镜手术,13例行传统手术;1例行单纯放疗。结果早期嗅神经母细胞瘤（A期＋B期）患者5年生存率为77.8%,晚期嗅神经母细胞瘤（C期）患者5年生存率为40.0%。鼻内镜手术治疗患者的5年生存率87.5%,传统手术治疗患者5年生存率为40.0%。结论早期嗅神经母细胞瘤患者预后较好,鼻内镜手术加术后放疗可以取得较好的疗效,颈部淋巴结转移患者预后欠佳。【Objective】To investigate the optimal treatment and prognostic factors of Esthesioneuroblastoma （ENB）.【Method】Clinical data of 28 cases with ENB,treated in our hosipital from May 1986 to December 2008,were reviewed retrospectively.According to Kadish classification,4 patients showed stage A,11 patients stage B,13 patients stage C.Of 27 cases were treated with surgery,14 patients were treated endoscopic approach,13 patients were treated with classic surgical approach,1 patient with radiotherapy alone.【Result】The 5-year survival rate is 77.8% in stage A and stage B,but the rate is 40.0% in advanced ENB.The 5-year survival rate is 87.5% in endo-scopic approach,the rate is 40.0% in classic surgical approach.【Conclusion】ENB has good prognosis in early stage,the endoscopic approach combine with radiotherapy after operation has a good prognosis.Cervical lymph node metastases has poor prognosis.

关 键 词：成感觉神经细胞瘤 鼻内镜 手术 预后 

分 类 号：R730.49[医药卫生—肿瘤]