E-cadherin、p120-catenin表达与肝细胞肝癌临床病理特征的关系  

Relationship between Expression of E-cadherin and p120-catenin and Clinicopathological Features in Human Hepatocellular Carcinoma

作　　者：靳文剑[1] 陈火国[1] 洪道显[1] 张焜和[2] 

机构地区：[1]江西省肿瘤医院内四科,南昌330029 [2]南昌大学第一附属医院消化科,南昌330006

出　　处：《南昌大学学报（医学版）》2010年第10期43-46,49,F0003,共6页Journal of Nanchang University：Medical Sciences

基　　金：江西省卫生厅科技课题(20063170)

摘　　要：目的探讨肝细胞肝癌(hepatocellular carcinomas,HCC)E-cadherin(E-cad)和p120-catenin(p120)表达与HCC患者临床病理特征的关系。方法应用EnVision法检测各80例HCC的表达情况,并比较二者在具有不同临床病理特征的肝癌间的表达差异。结果 E-cad、p120表达下调分别为:63.75%,70.00%。E-cad、p120表达下调与肿瘤分级密切相关(P<0.001)。p120的表达下调与肿瘤分期有明显相关(P<0.001)。肝癌中E-cad的表达下调与肝内转移和肝包膜浸润相关(均P<0.01)。p120的表达和肿瘤大小密切相关(P<0.001)。此外,p120表达和肿瘤肝内转移相关(P<0.05)。E-cad、p120的表达与淋巴结转移、血管侵袭和卫星灶差异无统计学意义。只有p120与AFP值表达相关(P<0.05)。结论肝细胞肝癌中E-cad、p120表达下调常常出现,且与肿瘤发生、发展相关。Objective To investigate the relationship between the expression of E-cadherin（E-cad） and p120 and the clinicopathological features in human hepatocellular carcinoma（HCC）.Methods Immunohistochemical staining for E-cad and p120 was performed using Envision method in 80 specimens from patients with HCC.Results E-cad expression and p120 expression decreased by 63.75% and 70.00%,respectively.The reduced expression of E-cad and p120 was significantly correlated with tumor grade（P0.001）,and the expression of p120 was correlated with tumor stage（P0.001）.The reduced expression of E-cad was significantly correlated with intrahepatic metastasis and capsular invasion（both P0.01）,and the expression of p120 was correlated with tumor size and intrahepatic metastasis（P0.001 and P0.05,respectively）.However,the expression of E-cad and p120 was not significantly correlated with lymph node metastasis,vascular invasion and satellite lesions.There was a correlation between p120 expression and AFP（P0.05）.Conclusion The reduced expression of E-cad and p120 occurs frequently in HCC and is correlated with HCC development and progression.

关 键 词：E-CADHERIN P120 肝细胞肝癌 免疫组化 临床病理特征 

分 类 号：R735.7[医药卫生—肿瘤]