气腹压力对裸鼠卵巢癌生长的影响  

Effect of pneumoperitoneum pressure on ovarian cancer growth in nude rats

作　　者：张团英[1] 陈旭[2] 张凤兰[1] 严兆华[1] 李元军[1] 黄美雯[1] 廖靖[1] 

机构地区：[1]广东医学院附属医院妇产科,广东湛江524001 [2]上海第二军医大学长征医院妇产科,上海200003

出　　处：《广东医学院学报》2010年第6期615-616,620,共3页Journal of Guangdong Medical College

基　　金：广东省科技计划资助项目(No.2007B031302002)

摘　　要：目的观察不同气腹压力对恶性肿瘤生长的影响。方法 45只裸鼠腹腔内种植人卵巢癌瘤块,成模后随机分为3组:无气腹组、低气腹组(5mmHg)、高气腹组(10mmHg),每组15只,模拟不同CO2气腹压力环境,时间为1h。术后4周开腹检查肿瘤生长平均质量,评价不同气腹压力对肿瘤生长的影响。结果高气腹组的肿瘤平均质量为(3245.3±72.2)mg,明显大于无气腹组的(1830.7±69.4)mg及低气腹组的(2362.4±71.3)mg,差异有统计学意义(P<0.01)。结论气腹压力增高可促进肿瘤生长,可能增加腹腔镜手术后肿瘤生长和种植转移机会。Objective To observe the effect of different pneumoperitoneum pressures on malignant tumor growth in nude rats. Methods Forty-five nude rats were implanted intraperitoneally by human ovarian cancer tissue. The animal models were randomly divided into null, low and high pressure groups, and each were treated with 0, 5 and 10 mmHg of CO2 pneumoperitoneum for 1 h. Tumor weight was measured 4 weeks after intervention. Results The tumor weight was （3245.3±72.2） mg, （2362.4±71.3） mg, and （1830.7±69.4） mg in high, low and null pressure groups, respectively, and there was a significant difference between them （P0.01）. Conclusion The increase of pneumoperitoneum pressure can enhance the tumor growth, suggestive of high risk of tumor growth and implantation metastasis after laparoscopic operation.

关 键 词：腹腔镜检查 气腹 恶性肿瘤 生长 转移 

分 类 号：R737.31[医药卫生—肿瘤]