后程加速超分割放疗同步周剂量紫杉醇方案治疗食管癌的临床研究  

The Study on Late Course Accelerated Fractionated Irradiation Combined with Concurrent Chemotherapy for Esophagus Squamous Cell Carcinoma

作　　者：马胜禄 崔史杰[2] 谢朝辉 丁柏英 刘丽华 蔡君东 甄晓兰 蒋静 李宝成 

机构地区：[1]河北省承德市肿瘤医院,河北承德067000 [2]河北医科大学研究生学院,河北石家庄050017

出　　处：《中国医药指南》2011年第8期5-6,共2页Guide of China Medicine

基　　金：承德市科研指导计划项目(200621040)

摘　　要：目的观察放射治疗配合紫杉醇化疗对食管癌的临床疗效。方法对173例食管癌患者根据不同的治疗方法分为单纯放射治疗组(单放组)和放射治疗同步化疗组(放化疗组)。单放组80例,放疗DT 65～70Gy;放化疗组93例,放疗同时化疗,紫杉醇每周60mg。两组均随访2年。结果放化疗组的近期效果好于单放组,有显着性差异(P<0.05)。单放组1、2年生存率为51.3%(41/80)、32.5%(26/80),同步放化组为87.19%(81/93)、68.8%(64/93),两组差异有显着性(P<0.05)。结论同步放化疗优于单纯放射治疗,可明显提高食管癌的疗效。Objective To study the effect of radiotherapy combined with paclitaxel on esophageal cancer.Method 173 cases of esophageal cancer were divided into conventional radiotherapy to a total of 65～70Gy;combined group with received the same radiotherapy as simple irradiation group plus chemotherapy with weekly paclitaxel.Both groups were followed for 2 years.Result The short-term results of radiotherapy combined with chemotherapy was better than that of radiotherapy alone.The survival rates in the combined group were thus much better than those in simple irradiation group（P〈0.05）.The one and two year survival rate in combined were 87%,68.8%.The one and two year survival rate in simple irradiation group were 51.3%,32.5%.The difference between these two groups was statistically（P〈0.05）.Conclusion Radiotherapy combined with chemotherapy were thus much better than those in simple irradiation group for advanced esophageal cancer.

关 键 词：食管癌 化疗后程加速超分割放疗 紫杉醇 

分 类 号：R735.1[医药卫生—肿瘤]