艾叶油的呼吸系统药理研究-Ⅱ,抗过敏作用  

Studies on the respiratory pharmacology of essential oil extracted from Artemisia argyi-Ⅱ,effects of antianaphylactic effects

作　　者：谢强敏[1] 唐法娣[1] 王砚[1] 杨秋火 卞如濂[1] 

机构地区：[1]浙江大学国家医药管理局新药研究管理中心浙江呼吸药物研究实验室,杭州310031

出　　处：《中国现代应用药学》1999年第5期3-6,共4页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的：本文研究艾叶油的抗过敏作用。方法：采用致敏豚鼠气管ＳｃｈｕｌｔｚＤａｌｅ 反应，组胺或氨甲酰胆碱引起的豚鼠气管收缩，大鼠被动皮肤过敏，５羟色胺引起的大鼠皮肤毛细血管通透性增强，豚鼠肺组织释放过敏性慢反应物质（ＳＲＳＡ） ，ＳＲＳＡ 收缩豚鼠回肠等试验。结果：艾叶油抑制致敏豚鼠气管ＳｃｈｕｌｔｚＤａｌｅ 反应（ＩＣ５０ ：９８ ．６ｍｇ／Ｌ） ；１００ｍｇ／Ｌ 明显降低组胺或氨甲酰胆碱引起的豚鼠气管收缩ｐＤ２ 值；明显抑制大鼠被动皮肤过敏（ＩＤ５０ ：０ ．２２ｇ／ｋｇ） 和５羟色胺引起的大鼠皮肤毛细血管通透性增强反应（ＩＤ５０ ：０ ．５２ｇ／ｋｇ） ；抑制豚鼠肺组织释放ＳＲＳＡ（ＩＣ５０ ：４９ ．７ｍｇ／Ｌ） ；拮抗ＳＲＳＡ 对豚鼠回肠的收缩（ＩＣ５０ ：３４ ．９ｍｇ／Ｌ） 。结论：艾叶油具有抗过敏作用，对呼吸道过敏反应有保护作用。OBJECTIVE:To evaluate the antianaphylactic effects of essential oil extracted from Artemisia argyi.METHODS:The following experiments were carrind out:tracheal Schultz Dale reaction in the sensitized guinea pigs,histamine or carbarylcholine induced tracheal contraction in guinea pig,the passive cutaneous anaphylaxis and 5 HT induced cutaneous capillary permeability in rats,the release of SRS A in the lung of guinea pigs,and SRS A induced ileum contraction in guinea pig.RESULTS:The oil of Artemisia argyi inhibited the tracheal Schultz Dale reaction in the sensitized guinea pigs(IC 50 :98.6mg/L).At the concentration of 100mg/L,the oil inhibited histamine or carbarylcholine induced tracheal contraction in guinea pig,shifting the dose effect curve to the right.Moreover,the oil significantly inhibited the passive cutaneous anaphylaxis and 5 HT induced cutaneous capillary permeability in rats(ID 50 :0.22 and 0.52g/kg),inhibited the release of SRS A in the lung of guinea pigs(IC 50 :49.7mg/L),and inhibited the SRS A induced ileum contraction in guinea pig(IC 50 :34.9mg/L)as well.CONCLUSION:Oil of Artemisia argyi has the effects of antianaphylaxis.It is beneficial for the treatment of asthma and chronic bronchitis.

关 键 词：艾叶油 色甘酸钠 抗过敏药 卵白蛋白 组胺 

分 类 号：R976[医药卫生—药品]