自发性腹膜炎腹水G-CSF测定的临床意义  

The Clinical Significance of Measurement of G CSF in Spontaneous Bacterial Peritonitis

作　　者：赵金满[1] 刘延君[1] 傅宝玉[1] 刘力[2] 赵洪光 

机构地区：[1]中国医科大学第一临床学院内科,沈阳110001 [2]沈阳矿务局医院 [3]铁法矿务局医院

出　　处：《中国医科大学学报》1999年第5期360-361,共2页Journal of China Medical University

摘　　要：目的：探讨自发性腹膜炎腹水粒细胞集落刺激因子（Ｇ－ＣＳＦ）测定的临床意义。方法：应用酶联免疫技术测定２５ 例自发性腹膜炎和２５ 例非细菌感染性腹水患者腹水中的Ｇ－ＣＳＦ。结果：在自发性腹膜炎患者腹水中Ｇ－ＣＳＦ阳性率（９２％ ）明显高于非细菌感染性腹水中的阳性率（４％ ），其差异有显著统计学意义（Ｐ＜ ０．００１）。其敏感性为９２％ ，特异性为９６％ 。并且腹水中的Ｇ－ＣＳＦ水平明显高于血清中的水平。随着自发性腹膜炎感染的控制，腹水Ｇ－ＣＳＦ水平逐渐降至正常。结论：腹水Ｇ－ＣＳＦ检测可有效区别自发性腹膜炎与非感染性腹水。Objective: We studied the clinical significance of measurement of granulocyte colony stimulating factor (G CSF) in ascites of spontaneous bacterial peritonitis (SBP) cases. Methods: G CSF in ascites patients of 25 with SBP and 25 non bacterial infective ascites patients was measured with enzyme linked immunosorbent assay. Results: The positive rate of G CSF in SBP ascites (92%) was much higher than that in non bacterial infective ascites (4%) (P<0.001). Sensitivity and specificity of the measurements were 92% and 96% respectively. G CSF in ascites was higher than that in serum. With the controll of SBP, the level of G CSF decreased to normal. Conclusion: Measurement of G CSF in ascites may be a useful method for differentiating SBP from non bacterial infective ascites. It is also helpful for physician to diagnose SBP earlier by and to observe treatment effects.

关 键 词：自发性 腹膜炎 腹水 粒细胞 集落刺激因子 G-CSF 

分 类 号：R572.2[医药卫生—消化系统] R442.5[医药卫生—内科学]