光动力疗法治疗复发耐药晚期食管癌疗效观察  

作　　者：朱琳[1] 库建伟[1] 

机构地区：[1]南阳医学高等专科学校第一附属医院肿瘤科,河南南阳473058

出　　处：《医学信息（中旬刊）》2011年第3期886-887,共2页Medical Information Operations Sciences Fascicule

摘　　要：目的:探讨光动力疗法治疗复发耐药晚期食管癌疗效及安全性。方法:对33例复发耐药晚期食管癌患者行1-5周期光动力治疗,每周期光动力照射治疗2-3次,2次间隔24小时,以1月为一周期。治疗结束后均随访2-12个月,疗效观察标准按照全国光动力学疗法学术会议拟订的标准执行,患者主观症状及内镜表现均纳入随访指标。结果:33例患者全部对治疗有效,内镜下观察病变缩小,主观症状缓解;其中6例进食梗阻感或胸骨后疼痛明显缓解,27例症状部分缓解。全部患者均可耐受治疗,无严重并发症发生。结论:光动力治疗复发耐药晚期食管癌是一种安全、有效的治疗手段,值得推广应用。Objective：To evaluate the efficacy and safety of photodynamic therapy （PDT） on patients with relapsing,drug-resisting and advanced esophageal carcinoma.Methods：33 patients with relapsing,drug-resisting and advanced esophageal carcinoma underwent 1 to 5 periodic treatments of PDT.A period of time,including 2 or 3 times of PDT,was a month.The follow up period for the 33 patients was from 2 to 12 months.Treatment response of the tumors was determined by follow-up endoscopies and the patients＇ subjective symptoms,and the standards of assessment were set by the national academic conference of PDT.Results：Symptomatic palliation,such as lesion reduced and subjective symptoms relieved,was observed in all of the patients.Significant effectiveness on obstruction or retrosternalpain was observed in six cases.Every patient had a good tolerance for PDT.No serious complications occured.Conclusion：PDT appears to be a secure,effective treatment for the patients with relapsing,drug-resisting and advanced esophageal cancer.

关 键 词：光动力治疗 复发耐药 晚期食管癌 

分 类 号：R730.5[医药卫生—肿瘤]