多西他赛不同给药方案联合卡培他滨治疗转移性乳腺癌的临床观察  

The clinical observation of Docetaxel with weekly and 3 weekly schema combined with Capecitabine for treating metastatic breast cancer

作　　者：毛海燕[1] 童建东[1] 汪竹[1] 殷旭东[1] 袁昕[1] 

机构地区：[1]扬州市第一人民医院,江苏扬州225000

出　　处：《中国民康医学》2011年第6期658-659,667,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:观察多西他赛不同给药方案联合卡培他滨治疗转移性乳腺癌的疗效和毒副反应。方法:26例转移性乳腺癌患者均接受多西他赛联合卡培他滨方案治疗1,2例多西他赛每周给药剂量为25mg/m2,d18,1,5;卡培他滨1 000mg,2次/d,d1～14。14例多西他赛三周给药剂量为75mg/m2,d1;卡培他滨1000mg,2次/d,d1～14,每3周为1周期。评价两组的有效率及毒副反应。结果:每周组12例患者完全缓解(CR)1例,部分缓解(PR)3例,有效率(CR+PR)33.3%(4/12)。三周组14例患者完全缓解(CR)1例,部分缓解(PR)4例,有效率(CR+PR)35.7%(5/14)。三周组的III～IV度血液学毒性及胃肠道反应均较每周组高,而三周组的周围神经炎较每周组低。结论:多西他赛联合卡培他滨是治疗转移性乳腺癌的有效方案之一,不同给药方案耐受性不同。Objective：To compare the efficacy and toxicity of Docetaxel with weekly and 3 weekly schema combined with Capecitabine for treating metastatic breast cancer.Methods：26 patients of metastatic breast cancer were given Docetaxel and Capecitabine,12 of them with weekly Docetaxel,about 25mg/m 2,d1.8.15,14 of them with 3 weekly Docetaxel,about 75mg/m 2,d1,both of them were given 1 000mg Capecitabine,twice a day for 14 days.Three weeks called one cycle.Efficacy and toxicity were evaluated.Results：In weekly group 1 patient achieved CR,3 patients achieved PR.The response rate（RR）was 33.3%,while in 3 weekly group 1 patient achieved CR,4 patients achieved PR.The response rate（RR） was 35.7%.The Ⅲ-Ⅳ grade hematologic toxicity and adverse reaction of gastrointestinal tract in 3 weekly group were higner than weekly group.While the peripheral neuritis in 3 weekly group were lower than weekly group.Conclusion：Docetaxel with Capecitabine was one of the available schemas for treating metastatic breast cancer.Differient dosage of docetaxel will achieve differient tolerance for different patients.

关 键 词：多西他赛 卡培他滨 转移性乳腺癌 

分 类 号：R737.9[医药卫生—肿瘤]