集束化治疗对严重脓毒症患者循环灌注和乳酸清除率的影响  

Effect of Sepsis Bundles on Circulation and Lactate Clearance Rate of Patients with Severe Sepsis

作　　者：邹毅成[1] 李轶男[1] 周立新[1] 誉铁鸥[1] 方滨[1] 强新华[1] 黎昌[1] 黎文研[1] 邵劲松[1] 

机构地区：[1]广东省佛山市第一人民医院ICU,528000

出　　处：《岭南急诊医学杂志》2011年第1期4-5,29,共3页Lingnan Journal of Emergency Medicine

基　　金：广东省佛山市重点科技攻关项目(200708029)

摘　　要：目的:研究集束化治疗对综合ICU严重脓毒症患者循环灌注和乳酸清除率的影响。方法:将2007年10月至2009年12月我科收治的18岁以上严重脓毒症患者63例随机分配入集束化治疗组和对照组,观察两组患者心率(HR)、血压(BP)、中心静脉压(CVP)、中心静脉血氧饱和度(ScvO_2)、动脉血乳酸(LAC)及乳酸清除率的变化。结果:集束化治疗组HR、SBP和DBP与对照组同期比较差异无统计学意义,但集束化治疗组入选后6 h CVP和ScvO_2明显高于对照组同期,LAC明显低于对照组同期(P<0.05),入选后24 h CVP和ScvO_2仍高于对照组同期,LAC仍低于对照组同期,但仅LAC的变化差异具有统计学意义(P<0.05),集束化治疗组6 h和24 h乳酸清除率均明显高于对照组同期,差异具有统计学意义(P<0.01)。结论:集束化治疗可以明显改善严重脓毒症患者早期的循环灌注。Objective：To study the effect of sepsis bundles on circulation and lactate clearance rate of patients with severe sepsis. Methods： Patients with severe sepsis with 18 years older at the ICU from Oct,2004 to Dec, 2007 were randomly divided into sepsis bundle group and control group.HR,BP,CVP,ScvO2,LAC and lactate clearance rate were recorded. Results： Compared with the control group, HR,SBP and DBP were no statistical significance, CVP and ScvO2 and LAC decreased significantly after 6 h. Lactate clearance rate after 6 and 24 h in bundle group were significantly higher than those in the control group. Conclusion： Application of the sepsis bundles could improve the early circulation of patients with severe sepsis.

关 键 词：集束化治疗 严重脓毒症 循环 乳酸 乳酸清除率 

分 类 号：R459.7[医药卫生—急诊医学]