GRPR在宫颈疾病中的表达及临床意义  

Clinical Significance and Expression of Gastrin-releasing Peptide Receptor in Cervical Diseases

作　　者：郑丹 张志强[2] 谭文华[3] 

机构地区：[1]哈尔滨市红十字中心医院妇产科,黑龙江哈尔滨150076 [2]哈尔滨市第一医院普外科,黑龙江哈尔滨150010 [3]哈尔滨医科大学附属第二医院妇产科,黑龙江哈尔滨150086

出　　处：《现代生物医学进展》2011年第3期530-533,共4页Progress in Modern Biomedicine

基　　金：黑龙江省重点科技攻关指导项目计划(GZ09C112)

摘　　要：目的:研究胃泌素释放肽受体(GRPR)在正常宫颈组织、宫颈上皮内瘤样病变(CIN)、宫颈癌中的表达,探讨GRPR在促癌发生和癌生长等方面的生物学功能。方法:采用免疫组化SP法检测GRPR在28例宫颈癌、51例宫颈上皮内瘤变和15例正常宫颈组织中的表达情况,其中以正常宫颈组织作为对照。结果:在正常宫颈和宫颈癌组织中,GRPR阳性表达率分别为20%和92.9%。GRPR在CINⅠ、CINⅡ、CINⅢ中阳性表达呈上升趋势,差别无统计学意义。宫颈癌组的不同临床分期、有无淋巴结转移组间比较,GRPR的阳性表达率均有显著性差异,并随病情严重程度的增加,阳性率增高,其表达强度呈显著正相关。结论:GRPR的过度表达与宫颈癌的发生、发展有关,是宫颈癌发生的早期事件,其检测可作为评估宫颈癌恶性程度、判断预后及指导治疗的重要参考指标。Objective：To investigate the expression of GRPR in normal cervical tissue,CIN and cervical cancer,and to explore the function of the GRPR during the incidence and growth in tumor promotion.Methods：The expression of GRPR in 28 cases of cervical cancer,51 cases of CIN and 15 cases of normal cervical tissues was detected by immunohistochemical staining,while the normal cervical tissue were used as normal control.Results：In normal cervix and cervical cancer tissues,GRPR positive expression rates were 20% and 92.9% The expression of the GRPR in CINⅠ,CINⅡ,CINⅢ showed an upward trend,and the difference was no significant.Between the groups of different clinical stages of cervical cancer,availability of lymph node metastasis,the positive expression rate of GRPR had significant difference,and with the increasing in the severity of the disease,the positive rate increased.And both intensity of expression was significantly positively related to.Conclusions：The over-expression of GRPR was associated with the occurrence and the develop-ment of cervical cancer,and the two indexes joint-detection can be used as assessment of the degree of malignancy of cervical cancer.

关 键 词：GRPR 宫颈癌 宫颈上皮内瘤变 

分 类 号：R737.3[医药卫生—肿瘤]