血管生成与喉癌侵袭、转移的研究进展  

Research progress of angiogenesis in invasion and metastasis of laryngeal carcinoma

作　　者：王树楹 吕梅[2] 杜翠萍[2] 吴丽华[2] 姚艺文[2] 

机构地区：[1]大连市第六人民医院耳鼻咽喉科,辽宁大连116001 [2]大连医科大学附属第一医院耳鼻咽喉科,辽宁大连116011

出　　处：《大连医科大学学报》2011年第1期86-89,共4页Journal of Dalian Medical University

摘　　要：新生毛细血管的形成,对喉癌肿瘤细胞本身的增殖和生长是必不可少的,同时也是肿瘤侵袭、转移的必要条件。在肿瘤血管形成的机制中血管生成调节因子起着关键作用,这些因子能够控制血管生成发生、发展以及终止过程,并作为抗血管生成治疗的分子靶点受到关注。本文综述了比较重要的几种细胞活性因子:血管内皮生长因子(VEGF)、基质金属蛋白酶(MMP)、整合素、血管生成素等在喉癌血管生成方面的临床意义。Angiogenesis is necessary for the cellular proliferation and growth of laryngeal carcinoma and is essential for tumor invasion and metastasis.Angiogenic regulatory factors play important roles in the mechanism of tumor neovascularization,controlling the development and termination of angiogenic progress.So they became the main targets for antiangiogenic therapies.We reviewed several representative cytokines regarding their clinical significance in laryngeal carcinoma,such as vascular endothelial growth factor（VEGF）,matrix metalloproteinase（MMPs）,integrin and angiogenin.

关 键 词：血管生成 喉癌 细胞因子 

分 类 号：R739.65[医药卫生—肿瘤]