冠心病患者的牙周状况与Fg和hs-CRP相关性的研究  

Periodontal Status in Patients with Coronary Heart Disease and Fg and hs-CRP Correlation

作　　者：钟慧敏[1] 常春荣[1] 张建全[1] 俞宁[1] 潘亚萍[1] 

机构地区：[1]中国医科大学口腔医学院牙周科,辽宁沈阳110002

出　　处：《口腔医学研究》2011年第2期123-126,共4页Journal of Oral Science Research

基　　金："十一五"国家科技支撑计划课题(2007BAI18B02);辽宁省科学技术计划项目(2007225007)

摘　　要：目的:通过牙周临床检查和血生化指标检测,观察冠心病患者的牙周状况,探讨纤维蛋白原和高敏C反应蛋白在两者间的相关关系。方法:按照冠心病及慢性牙周炎临床诊断标准随机选择200名研究对象,年龄35～80岁,分为急性冠脉综合征(ACS)组50人,慢性冠脉病(CAD)组50人,单纯慢性牙周炎(CP)组50人,健康(H)对照组50人,每组都进行牙周探诊深度(PD)、临床附着丧失度(CAL)、龈沟出血指数(SBI)和简化卫生指数(OHI-S)检查,采集清晨静脉血检测Fg和hs-CRP水平。结果:PD、CAL、OHI-S在ACS组中最高,与CP组比较有显著性差异(P<0.001);SBI在CAD组中最高,ACS组与CP组比较有显著性差异(P<0.001);Fg和hs-CRP在ACS组中测定值最高,与CP组比较有显著性差异(P<0.05);血生化指标Fg和hs-CRP的水平与牙周临床指标PD、CAL、SBI、OHI-S比较呈正相关(P<0.01)。结论:冠心病患者无论是急性期还是稳定期牙周状况都比单纯慢性牙周炎患者严重;PD、CAL、OHI-S的升高可引起血清中Fg和hs-CRP水平的变化,牙周临床指标的改变可能与冠心病的急性发作和加重冠心病病程有关。Objective：To observe the periodontal condition in patients with coronary heart disease and relationship between hs-CRP and Fg by periodontal clinical examination and serum biochemical parameters.Methods：The selected 200 subjects were aged 35-89 years old.A group of acute coronary syndrome was 50 persons.A group of chronic coronary artery disease was 50 persons.A group of simple chronic periodonititis was 50 persons.A healthy control group was 50 persons.Each group was checked probing depth（PD）,clinical attachment loss degrees（CAL）,gingival sulcus bleeding index（SBI） and simplified health index（OHI-S）.They were also collected blood in the morning to test the levels of hs-CRP and Fg,compared the levels of periodontal clinical parameters and difference between Fg and hs-CRP.Results：PD, CAL,OHI-S were the highest in the ACS group,which was statistically significant（P〈0.001） diffenent from CP group.SBI was the highest in the CAD group,which was significant different from the CP group（P〈0.001）.Fg and hs-CRP were the highest in the ACS group（P〈0.05）.Fg and hs-CRP was positively correlated compared with periodontal clinical parameters PD,CAL,SBI,OHI-S（P〈0.01）.Conclusion：The status of the periodontal patients with the coronary heart disease and with either acute phase or stable phase was worse than the status of the patients with simply chronic periodontitis.The increase of PD,CAL,OHI-S could lead to the levels of Fg and hs-CRP change,which were the important factors for the acute coronary heart disease and aggravate coronary heart disease.

关 键 词：慢性牙周炎 冠心病 FG HS-CRP 

分 类 号：R781.42[医药卫生—口腔医学]