痰热清在中晚期非小细胞肺癌放化疗中的应用  

The application of Tan-re-qing injection in chemotherapy and radiotherapy to advanced non-small-cell lung cancer

作　　者：姚春梅[1] 尹刘[1] 

机构地区：[1]安徽省淮北矿工总医院肿瘤科,淮北235000

出　　处：《临床医学》2011年第3期34-35,共2页Clinical Medicine

摘　　要：目的观察中晚期非小细胞肺癌(NSCLC)患者同步化疗(CT)及三维适形放射治疗(3DCRT),加用痰热清注射液能否减轻治疗的肺毒性反应。方法观察组(同步CT+3DCRT+痰热清)与常规治疗组(同步CT+3DCRT)各39例。常规组治疗同步用紫杉醇+顺铂/紫杉醇+卡铂(TP/TC)方案化疗及3DCRT放疗,肺V20≤20%。观察组治疗同常规组外,在放疗30 Gy/15 Fx后加用痰热清20 ml/d,静脉滴注至放疗结束。两组在治疗过程中出现肺毒性反应时均加用地塞米松及抗炎和对症支持治疗。结果肺毒性反应总发生率观察组与常规组分别为33.3%和66.7%(P=0.02765),两组肺毒性发生的时间Ⅰ级分别为43.7 d和33.8 d,Ⅱ级分别为45.3 d和38.1 d(P<0.05);发生的剂量Ⅰ级分别是63.5 Gy和49.8 Gy(P<0.05),Ⅱ级分别是66.7 Gy和56.3 Gy(P<0.05)。结论痰热清值得进一步在NSCLC患者同步CT+3DCRT中扩大临床观察研究。Objective To observe whether or not apply Tan-re-qing injection to reduce lung toxic reactions for advanced NSCLC patient by radiotherapy with synchro 3DCRT.Methods Totally 78 cases,observation group（39 cases） and conventional treatment group（39 cases）.Apply TP/TC chemotherapy and 3DCRT radiotherapy for conventional treatment group,lung V20≤20%.Observation group got the same treatment,besides applying Tan-re-qing injection 20 ml each day after 30 Gy radiotherapy,and stop intravenous infusion at the end of radiotherapy.Apply dexamethasone with anti-inflammatory and symptomatic treatment support for the two groups when lung toxic reactions happen.Results The total occurrence of observation group and conventional treatment group were 33.3% and 66.7%（P=0.02765）.Time of occurrence of lung toxic reactions were 43.7 days and 33.8 days.Time Ⅱof occurrence were 45.3 day and 38.1 days（P0.05）.The dose Ⅰof occurrence were 63.5 Gy and 49.8 Gy（P0.05）,and the doseⅡof occurtence were 66.7 Gy and 56.3 Gy（P0.05）.Conclusion The research on the clinical observation of Tan-re-qing injection in NSCLC patients by chemotherapy and synchro radiotherapy is worth of being enlarged.

关 键 词：痰热清 同步化疗及三维适形放射治疗 肺毒性 中晚期非小细胞肺癌 

分 类 号：R734.2[医药卫生—肿瘤]