检测急性脑梗死患者血小板活化因子的临床意义  

Role of platelet activating factor in diagnosis and treatment of acute cerebral infarction

作　　者：尹黎英[1] 李惠媛[1] 张冀平[1] 王璇[1] 刘媛[1] 李建华[2] 

机构地区：[1]武警山西总队医院神经内科,太原030006 [2]太原市中心医院内科实验室,030001

出　　处：《武警医学》2011年第2期129-131,135,共4页Medical Journal of the Chinese People's Armed Police Force

摘　　要：目的探讨血小板活化因子(platelet activating factor,PAF)与脑梗死的关系,以及以PAF为靶点的药物对脑梗死的治疗意义。方法用双抗夹心ELISA法检测血浆PAF浓度;检测急性脑梗死患者经红花黄色素(safflower yellow,SY)治疗后的神经功能、PAF、血液流变学的变化。结果急性期脑梗死患者血浆PAF值明显高于健康对照组,且与梗死体积成正比;经SY治疗后急性脑梗死患者神经功能和血液流变学明显改善,血浆PAF值下降。结论急性脑梗死患者可出现PAF浓度增加,活性增强;针对PAF的药物可明显改善其神经功能和血液流变学。Objective To study the relationship between platelet activating factor （PAF） and acute cerebral infarction （ACI） , and the PAF as a target for ACI therapy. Methods PAF levels in plasma were quantified using enzyme - linked immunosorbent assay. Effects of safflower yellow （SY） on nervous function, PAF and hemorheology were tested to further prove the role of PAF in the treatment of ACI. Results The PAF levels in ACI group were significantly higher than those in healthy control group, and proportional to infarction volume. Improved nervous function and hemorheology, decreased PAF levels were observed after SY treatment. Conclusions PAF levels and activity are elevated in ACI patients, and the drug aimed at PAF plays a key role in the treatment of ACL.

关 键 词：血小板活化因子 急性脑梗死 红花黄色素 神经功能 

分 类 号：R364.17[医药卫生—病理学]