氟马西尼用于脑瘫患儿全麻催醒的临床研究  

CLINICAL STUDY ON FLUMAZENIL USING FOR ANALEPSIA OF CHILDREN WITH CEREBRAL PALSY AFTER GENERAL ANESTHESIA

作　　者：张科 叶章文 余学英 齐磊 

机构地区：[1]核工业416医院麻醉科,四川成都610051

出　　处：《河北医科大学学报》2011年第2期182-184,共3页Journal of Hebei Medical University

摘　　要：目的探讨氟马西尼用于脑瘫患儿全麻术后催醒的有效性和安全性。方法 40例行脑瘫手术的患儿,随机分为氟马西尼组(Ⅰ组)和生理盐水组(Ⅱ组)。前者在手术结束后经留置针注射氟马西尼0.006mg/kg,60s内清醒程度未达到要求再追加半量。Ⅱ组注射相同剂量的生理盐水。观察记录注射药物后5min患儿清醒率、注射药物时和注射药物后5min患儿的脑电双频指数(bispectral index,BIS)值以及清醒后30min内躁动和恶心、呕吐发生率。结果氟马西尼组注射药物后5min清醒率及BIS值均高于生理盐水组(P<0.05),2组患儿的躁动和恶心、呕吐发生率差异无统计学意义(P>0.05)。结论氟马西尼可以安全有效的用于脑瘫患儿的全麻术后催醒。Objective To determine the analeptic effectiveness and safety of flumazenil in child patients with cerebral palsy for recovery from general anesthesia. Methods Forty operated child patients with cerebral palsy were randomly divided into two groups （ n = 20 each ） . The patients in group I received flumazenil （0.006mg/kg, intravenous injection） after surgery, and patients in group II received normal saline. When patients could not be awakened in 60 seconds, they were given a half of the first dose once more. The alertness score and the bispeetral index （BIS） value in 5min before and after the injection were assessed, and adverse reactions such as nausea , vomiting and psychomotor agitation of all patients were also recorded. Results The alertness rate and BIS value were significantly higher in group I than those in group II. However, there were no significant difference in nausea, vomiting and psychomotor agitation found between two groups. Conclusion Flumazenil can be effectively and safely used for analepsia of children with cerebral palsy after general anesthesia.

关 键 词：氟马西尼 脑性瘫痪 麻醉 全身 

分 类 号：R742[医药卫生—神经病学与精神病学]