舍曲林治疗脑卒中伴抑郁患者的临床疗效观察  

The clinical efficacy sertraline treatment of depression after stroke associated

作　　者：马文娟[1] 

机构地区：[1]内蒙古医学院附属医院神经内科,010050

出　　处：《中国实用医药》2011年第6期29-30,共2页China Practical Medicine

摘　　要：目的评价抗抑郁药物舍曲林对脑卒中后抑郁患者的治疗效果,及对神经功能康复的影响,为临床治疗提供依据。方法将50例脑卒中患者按入院先后顺序随机分为两组,两组患者均接受脑卒中的常规治疗,包括脱水、降颅压、控制血压、抗凝、活血化瘀及纠正水电解质代谢紊乱,同时预防并发症等。治疗组在常规治疗的基础上同时给予舍曲林50 mg、1次/d口服,连续治疗1个月。结果两组汉密尔顿抑郁量表(HAMD)和神经功能缺损评分标准(改良爱丁堡一斯堪的那维亚卒中量表MESSS)有效率分别为88.0%、84.0%和52.0%、56.0%,两组有效率比较差异有统计学意义(P<0.01)。结论舍曲林可明显改善脑卒中后继发抑郁症的情况,说明舍曲林可以用于脑卒中的治疗。Objective To evaluate the antidepressant Sertraline in patients with depression after stroke treatment,and the rehabilitation of neurological function,provide the basis for clinical treatment.Methods 36 stroke patients were randomly divided into two groups according to the order of admission,all patients received conventional treatment of stroke,including dehydration,reduced intracranial pressure,control blood pressure,coagulation,blood circulation and correcting water and electrolyte metabolism at the same time to prevent complications.The treatment group were also given on the basis of treatment Sertraline 50 mg,once abay,continuous treatment for 1 month.Results Two Hamilton Depression Rating Scale（HAMD）and neurological deficit scoring（modified Edinburgh-Scandinavian Stroke Scale MESSS）rates were 88%,84%and 52%,56%,the efficiency of the two groups there were significant differences（P〈0.01）.Conclusion Sertraline may improve post-stroke depression secondary to the situation,that can be used for stroke sertraline treatment.

关 键 词：舍曲林 脑卒中 抑郁症 神经功能康复 

分 类 号：R743[医药卫生—神经病学与精神病学] R749.4[医药卫生—临床医学]