对常规IVF未受精周期不同时间实施补救ICSI的比较  

Comparison of rescue ICSI at different times of non-IVF cycles in conventional IVF

作　　者：朱丽霞[1] 席青松[1] 任新玲[1] 陈雯[1] 魏玉兰[1] 李豫峰[1] 章汉旺[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院妇产科,湖北武汉430030

出　　处：《中国妇幼保健》2011年第9期1388-1390,共3页Maternal and Child Health Care of China

摘　　要：目的:比较常规体外受精(IVF)中未受精的病例在不同时间行补救卵胞浆内单精子注射(ICSI)再受精的临床结局,以探讨补救ICSI的临床应用价值及最佳的补救时机。方法:回顾性分析2007年1月～2009年7月在华中科技大学同济医学院附属同济医院生殖医学中心接受常规IVF治疗未受精并实施补救ICSI的93例患者,根据补救ICSI实施时间的不同,分为晚补救组(常规体外受精后20～22 h实施补救ICSI1,6例)和早补救组(常规体外受精后4～8 h实施补救ICSI7,7例)。结果:晚补救组与早补救组在女性年龄、不孕年限、平均每周期获卵数方面进行比较均无统计学差异(P>0.05)。但晚补救组的正常受精率、卵裂率和妊娠率都低于早补救组(52.0%vs63.0%,87.5%vs94.1%,0%vs43.5%),两组之间比较差异具有统计学意义(P<0.05)。结论:常规IVF受精失败后行补救ICSI再受精是切实可行的,而合理的补救时间是获得理想临床结局的关键。Objective：To compare the clinical outcomes of rescue intracytoplasmic sperm injection（ICSI） at different times of non-IVF cycles in conventional IVF,explore its clinical application value and the optimal rescue time. Methods：93 cases receiving conventional IVF and rescue ICSI in the hospital from January 2007 to July 2009 were analyzed retrospectively;according to the different rescue ICSI times,they were divided into late rescue ICSI group（rescue ICSI was performed at 20～22 hours after conventional IVF,16 cases） and early rescue ICSI group（rescue ICSI was performed at 4～8 hours after conventional IVF,77 cases）. Results：There was no significant difference in maternal age,duration of infertility and the mean number of oocytes retrieved every cycle between the two groups（P〉0.05）.The normal fertilization rate,cleavage rate and pregnancy rate in late rescue ICSI group were significantly lower than those in early rescue ICSI group（52.0% vs 63.0%,87.5% vs 94.1%,0% vs 43.5%,respectively）（P〈0.05）. Conclusion：Rescue ICSI is effective if fertilization is failure after routine IVF,and reasonable rescue time is the key of achieving ideal clinical outcome.

关 键 词：ICSI 早补救 体外受精 受精失败 妊娠率 受精率 

分 类 号：R-33[医药卫生]