HMGB1与临床疾病关系的研究进展  

Advanced study on the relationship between HMGB1 and diseases

作　　者：徐海洲(综述)[1] 何建(审校)[1] 

机构地区：[1]解放军第二军医大学附属长海医院急诊科,上海200433

出　　处：《中国急救医学》2011年第3期264-268,共5页Chinese Journal of Critical Care Medicine

摘　　要：高迁移率族蛋白是一种高度保守的DNA 结合蛋白,广泛存在于哺乳动物体内.在核内参与核小体的构建和稳定,调节基因的转录.在核外可介导炎症反应、促进细胞分化及肿瘤生长等.其释放途径主要为主动分泌和被动释放,通过与RAGE、TLR2、TLR4等受体结合,激活相应信号传导途径.近来研究发现,HMGB1与脓毒症、肿瘤、风湿免疫、动脉粥样硬化、缺血再灌注损伤等多种疾病密切相关,本文就此作一综述.High mobility group box - 1 （ HMGB1 ）, a highly conservative DNA - binding protein, exists ubiquitously in the ceils of mammals. It contributes to maintaining the structure of nucleosome and modulating transcription of gene in nuclei, while out of the nuclei it involves in sepsis mediation, tumor development, cell differentiation and so on. HMGBI is secreted actively by macrophage/monocyte and released passively during cell death. Through binding with its reeeptors such as RAGE, TLR2, TLR4, HMGB1 can stimulate the corresponding signal transduction pathway. Recent studies have revealed that HMGB1 is closely related with sepsis, tumor, rheumatic and autoimmune disease, atherosclerosis and ischemia- reperfusion injury. In this article, we briefly review the correlation between HMGB1 and these diseases.

关 键 词：高迁移率族蛋白类 脓毒症 肿瘤 风湿免疫病 动脉粥样硬化 缺血再灌注 

分 类 号：R394[医药卫生—医学遗传学]