食管鳞癌组织中胆囊收缩素B受体的表达  

Expression of cholecystokinin receptor B type in esophageal cancer tissues

作　　者：黄东凤[1] 张弘[1] 潘骅[1] 章建国[2] 黄华[2] 

机构地区：[1]南通大学附属医院消化病科,226001 [2]南通大学附属医院病理科,226001

出　　处：《江苏医药》2011年第3期329-331,I0001,共4页Jiangsu Medical Journal

摘　　要：目的探讨胆囊收缩素B(CCK-B)受体在人食管鳞癌(EC)组织及EC旁组织中的表达。方法收集EC组织标本30例和对应癌旁正常食管组织,采用RT-PCR法检测EC和癌旁组织中CCK-B受体mRNA的表达;免疫组化染色法检测CCK-B受体蛋白在EC组织中的表达水平以及与临床分期和病理分级之间的关系。结果 30例EC组织中有27例(90.0%)CCK-B受体mRNA呈阳性,癌旁正常组织呈阴性表达;30例EC组织中CCK-B受体有25例(83.3%)呈阳性表达。EC组织不同病理学分级各组间CCK-B受体阳性表达率经统计学处理,无统计学差异。结论 CCK-B受体的表达是EC发生的早期事件,可用作EC临床诊断的生物学标志。Objective To investigate the expression of cholecystokinin B type（CCK-B ） receptor in esophageal cancer tissues.Methods The expressions of CCK-B receptor mRNA and protein were detected by RT-PCR and immunohistochemistry staining in 30 esophageal cancer tissues and the tumor-adjacent tissues.The relationship of CCK-B receptor expression with the clinical stage and pathological grade was analyzed.Results Of 30 esophageal cancer tissues,CCK-B receptor mRNA expression was positive in 27 cases（90.0%）,which was all negative in the tumor-adjacent tissues.The CCK-B receptor expression was positive in 25 cases（83.3%） in 30 esophageal cancer tissues,which was all negative in the tumor-adjacent tissues. No significant difference was found among the clinical stage and pathological grade groups.Conclusion The expression of CCK-B receptor is an early event in the esophageal carcinogenesis and may be taken as a biological marker in diagnosis of EC.

关 键 词：食管鳞癌 胆囊收缩素受体 

分 类 号：R571[医药卫生—消化系统]