信号传导与转录激活因子3和E-钙黏蛋白及波形蛋白在结肠癌组织中的表达及其临床意义  

Clinical significance of signal transduction and activators of transcription 3, E-cadherin and vimentin in colon cancer

作　　者：张超[1] 徐建华[1] 刘涛[1] 崔浩[1] 

机构地区：[1]第三军医大学附属西南医院全军普通外科中心微创胃肠外科中心,重庆400038

出　　处：《中华胃肠外科杂志》2011年第3期202-205,共4页Chinese Journal of Gastrointestinal Surgery

基　　金：全军医学科研“十一五”计划面上项目（06MB243）

摘　　要：目的探讨信号传导与转录激活因子3（STAT3）和E-钙黏蛋白（E—cadherin）及波形蛋白（vimentin）在结肠癌组织中的表达及其临床意义。方法收集70例结肠癌患者结肠癌组织和相应癌旁组织标本．应用免疫组织化学方法检测STAT3、E-cadherin和vimentin的表达，分析其与结肠癌临床病理特征的关系及三者表达之间的相关性。结果STAT3、E-cadherin及vimentin在结肠癌组织中阳性表达分别为52例（74．3％）、23例（32．9％）和55例（78．6％），在癌旁组织阳性表达分别为13例（15．7％）、58例（82．9％）和9例（12．9％），差异均有统计学意义（均P〈0．01）。STAT3、E-cadherin及vimentin的表达均与肿瘤分化程度、浸润深度、淋巴结转移及TNM分期有关（均P〈0．05）。STAT3表达与vimentin表达呈正相关．而与E-cadherin表达呈负相关（均P〈0．01）。结论STAT3、E-cadherin及vimentin与结肠癌关系密切，其表达水平可作为判断结肠癌病程和预后的参考指标之一．Objective To evaluate the clinical significance of STAT3, E-cadherin and vimentin in colon cancer. Methods Samples of colon cancer tissue and adjacent normal tissue were procured from 70 patients with colon cancer. The expressions of STAT3, E-eadherin and vimentin were detected by immunohistochemistry. Associations of clinicopathologieal characteristics and these three factors were evaluated. Results STAT3, E-cadherin, vimentin were positive in 74.3%,32.9%, and 78.6% in the colon cancer tissues, respectively, and were 15.7%, 82.9%, and 12.9% in normal colon mucosa tissues, respectively. They were correlated with tumor differentiation, depth of invasion, lymph node metastasis, and TNM staging （P〈0.05）. There was a positive correlation between STAT3 and vimentin expression （P〈0.01）. However, STAT3 was negatively correlated with E-cadherin （P〈0.01）. Conclusions STAT3, E-cadherin and vimentin are closely associated with colon cancer. The expressions of STAT3, E-cadherin and vimentin may serve as prognostic indicators for patients with colon cancer.

关 键 词：结肠肿瘤 信号传导与转录激活因子3 E-钙黏蛋白 波形蛋白 

分 类 号：R735.35[医药卫生—肿瘤]