左侧乳腺癌术后放疗患者PET—CT上心脏主要亚结构勾画的可行性研究  被引量:13

Delineation of the cardiac sub-structures based on PET-CT in patients with left-sided breast cancertreated with post-operative radiotherapy

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作  者:俞晓立[1] 陈佳艺[1] 郭小毛[1] 陈兰飞[1] 潘自强[1] 章真[1] 胡四龙[2] 章英剑[2] 冯炎[1] 

机构地区:[1]复旦大学上海医学院肿瘤学系 复旦大学附属肿瘤医院放疗科,上海200032 [2]复旦大学上海医学院肿瘤学系复旦大学附属肿瘤医院核医学科,上海200032

出  处:《中华放射肿瘤学杂志》2011年第2期128-132,共5页Chinese Journal of Radiation Oncology

基  金:上海市科委项目(44119656);复旦大学青年科学基金资助(2006-12)

摘  要:目的探讨PET-CT对左侧乳腺癌术后放疗患者左心室(LV)显示和心脏亚结构[IJV及左侧冠状动脉前降支(LAD)]勾画,以及心脏、心脏亚结构放疗剂量体积间关系。方法2008—2009年问14例左侧乳腺癌患者进入本研究,放疗前接受氟脱氧葡萄糖PET—CTLV心肌显像扫描,继而用ADACPinnacle^37.6c计划系统与增强定位CT融合。LV在PET—CT图像上勾画,LAD的勾画参考前室间隔解剖及增强CT图像。放疗计划采用6个野简化调强放疗(sIMRT)技术,并用Pearson法分析sIMRT下心脏与亚结构接受≥50%处方剂量(25Gy)的体积占总体积百分比(V25)间关系。结果14例患者PET—CT图像勾画的LV体积(LV—PET)均值为112.9310131cm^3。心脏V25与LV—PET V25,间呈正相关(R=0.869,P=0.000),心脏V25与LAD—cTVV25问无关(R=0.220,P=0.440)。结论对左侧乳腺癌患者以PET.CTLV代谢显像为基础能有效勾画LV解剖结构,sIMRT计划显示了心脏与其亚结构的剂量体积问关系,为进一步分析这些正常组织的放射损伤提供了量化的基础和可能。Objective To evaluate the volume of left ventricle (LV) based on PET-CT in left-sided breast cancer patients treated with adjuvant radiotherapy. To assess the impact of dose and volume in interrelations for heart and cardiac sub-structures using dose-volume histograms. Methods From October 2008 to February 2009, 14 patients with post-operatively confirmed left-sided breast cancer were enrolled in this study. Patients were scanned using contrast enhanced CT for simulation and FDG PET-CT have been applied to display the structure of left ventricle in each patient before radiotherapy (RT). Tile LV has been delineated based on PET-CT. Other critical sub-structures, such as left anterior descending coronary artery (LAD) have been contoured in each patient. The six-field simple intensity modulated radiotherapy (sIMRT) technique has been created in all patients. Results The mean volumes of left ventricle based on PET-CT (LV-PET) were 112. 931 cm^3. The volume of LV receiving≥50% prescription dose highly correlated with the volume of heart receiving ≥50% prescription dose (R = 0. 869 ,P=0. 000). There was less correlation between the volume of LAD and the volume of heart receiving≥50% prescription dose ( R = 0. 220, P = 0. 440). Conclusions The left ventricle could be delineated efficiently based on imaging of PET-CT. The volume of LV receiving higher dose in RT has high correlation with the volume of heart using sIMRT technique. It may pave the way for further exploring radiation induced cardiac injury in patients with breast

关 键 词:乳腺肿瘤/放射疗法 体层摄影术 发射型计算机 心脏亚结构 

分 类 号:R730[医药卫生—肿瘤] R737[医药卫生—临床医学]

 

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