假性肥大型肌营养不良儿童血清脑利钠肽水平与心脏功能的相关性  

Correlation Between Serum B-Type Natriuretic Peptide Levels and Cardiac Function in Duchenne's Muscular Dystrophy Patients

作　　者：田淑芬[1] 

机构地区：[1]贵阳医学院附属医院神经内科,贵州贵阳550004

出　　处：《武汉大学学报（医学版）》2011年第2期219-221,共3页Medical Journal of Wuhan University

基　　金：贵州省科学技术基金项目(编号:[2009]2163)

摘　　要：目的:研究假肥大型肌营养不良(DMD)患者血清脑利钠肽(BNP)与左心室功能的相关性。方法:采用电化学发光免疫方法以及心脏超声检查分别测量50名DMD儿童和25名正常儿童的血清BNP水平和左心室功能相关指标。分析DMD儿童血清BNP与不同心脏功能分级的相关性。结果:DMD儿童血清BNP水平与左心室功能与正常对照组有显著性差异(P<0.01)。不同心脏功能分级的DMD儿童血清BNP水平和左心室功能显著不同(P<0.05或P<0.01)。DMD儿童LVMI、LVEDD、LVPWT与血清BNP水平正相关,LVEF、IVST、FS、E/A与血清BNP水平负相关(r绝对值:0.53-0.75,P<0.05)。结论:DMD儿童血清BNP水平与左心室功能显著相关,可作为诊断DMD儿童心脏功能的指标。Objective： To research the correlation between serum B-type natriuretic peptide（BNP） levels and function of left ventricle in Duchenne＇s muscular dystrophy（DMD） children.Methods： The serum BNP levels and function of left ventricle in 50 DMD children and 25 control children were detected respectively by electro-chemistry immunity assay and echocardiography,and the correlation between serum BNP levels and function of left ventricle in DMD children was analyzed.Results： The serum BNP levels and function of left ventricle were significantly different in statistics between DMD children and control children（P0.01）.The serum BNP levels and function of left ventricle were significantly different in DMD children with different NYHA grades（P0.05 or P0.01）.Left ventricular indices measured by echocardiograpy such as LVMI,LVEDD and LVPWT were positively correlated to serum BNP levels,but LVEF,IVST,FS,and E/A were negatively correlated to serum BNP levels in DMD children（｜r｜=0.53-0.75,P0.05）.Conclusion： Serum BNP levels correlate to the function of left ventricle,and could be used as the indicators to detect the cardiac function in DMD children.

关 键 词：假性肥大型肌营养不良 左心室功能 B型脑利钠肽 

分 类 号：R541.61[医药卫生—心血管疾病]