江苏省启东市2001—2007年结直肠癌患者生存率分析  

Survival of colo-rectum cancer cases in 2001-2007 in Qidong city,Jiangsu province,China

作　　者：陈永胜[1] 丁璐璐[1] 张永辉[1] 朱健[1] 陈建国[1] 

机构地区：[1]江苏省启东肝癌防治研究所,江苏启东226200

出　　处：《中国癌症杂志》2011年第2期134-139,共6页China Oncology

摘　　要：背景与目的:生存率是反映癌症预后的一个重要指标。本研究旨对启东2001—2007年全人群结直肠癌登记病例进行生存率分析,为预后评价及防治提供依据。方法:对来自启东肿瘤登记报告系统的1 508例病例的生存情况进行随访,随访时间截止于2009年12月31日;剔除只有死亡证明(DCO)的病例,实际纳入分析1 504例。用SURV 3.01软件计算5年观察生存率(observed survival,OS)及5年相对生存率(relative survival,RS)。结果:结直肠癌患者1、3、5年OS分别为58.50%、42.68%和37.74%,1、3、5年RS分别为60.97%、49.59%和48.67%。其中男性患者1、3、5年RS分别为62.68%、50.82%、48.88%,女性患者1、3、5年RS分别为59.24%、48.38%、48.50%。男女性生存率差异无统计学意义(χ2=3.18,P=0.528)。结肠癌与直肠癌患者的5年RS分别为56.61%与44.17%。15～34岁、35～44岁、45～54岁、55～64岁、65～74岁及75岁以上各年龄组的结直肠5年RS分别为42.22%、41.06%、50.02%、54.40%、50.11%和42.38%。结直肠癌患者5年RS比同一地区同类疾病1972—2000年时的28.00%有较大提高。结论:启东市全人群结直肠癌登记病例总体生存率有较大的提高,但与国外发达国家相比尚有差距。Background and purpose：Survival rate is one of the important indexes for cancer prognosis.Survival rates for the patients with colo-rectum cancer in the population-based cancer registry from the year of 2001 to 2007 in Qidong,China were analyzed.Methods：The last follow-up date for the assessment of survival statuses were December 31st,2009.A total of 1？504 cases were enrolled for study and DCO（death certificates only） cases were excluded.Cumulative observed survival rate（OS） and relative survival rate（RS） were calculated using Hakulinen＇s method and performed by the SURV3.01 software developed at the Finnish Cancer Registry.Results：The one-,three-,and five-year OS were 58.50%,42.68% and 37.74%,whereas the one-,three-,and five-year RS were 60.97%,49.59% and 48.67%,respectively.The one-,three-,and five-year relative survival rates of males vs females were 62.68% vs 59.24%,50.82% vs 48.38%,and 48.88% vs 48.50%,respectively,it showed no statistically significant differences（χ2=3.18,P=0.528）.The 5-year RS of colon cancer was 56.61%,and of rectum cancer,44.17%.Relative survival rates of age groups of 15-34,35-44,45-54,55-64,65-74,and 75＋ were 42.22%,41.06%,50.02%,54.40%,50.11% and 42.38%,respectively.There had been remarkable improvement in the 5-year RS in this setting（48.67%） if compared to the rate（28.00%） of the years of 1972-2000.Conclusion：The survival outcomes for colon and rectum cancers in Qidong have improved in the past decades,but there are still differences between China and other developed countries in terms of prognosis of the patients with colorectum cancer.

关 键 词：肿瘤/登记 生存率 流行病学 启东 

分 类 号：R735.3[医药卫生—肿瘤]