出 处:《中华医学杂志》2011年第7期445-450,共6页National Medical Journal of China
摘 要:目的观察单侧视盘出血(DH)的正常眼压性青光眼(NTG)患者出血眼的临床特征。方法回顾性分析37例单侧DH的NTG患者双眼间差异,观察指标包括眼压,屈光度,中央角膜厚度,视盘的面积、横径、纵径、横径/纵径,视盘的整体参数和DH所在区域的分区参数,视盘旁脉络膜萎缩灶B区(PPA)的发生率、面积、范围、最大宽度等。视盘而积及其他整体和分区参数通过应用海德堡视网膜断层扫描仪Ⅱ型(HRT—Ⅱ)测量获得,视盘的横径、纵径及PPA系列参数则通过使用计算机Image—pro plus6专业图像分析软件对视柱的HRT—Ⅱ图像进行分析获得。所得结果进行单因素及多因素¨归分析。结果DH组视盘的纵径较对侧组长(P〈0.叭),横径/纵径较对侧小(P=0.017),PPA的发牛牢较埘侧高(P=0.031),差异均有统计学意义。DH组视盘整体参数的视网膜神经纤维层平均厚度(G—MRNFLT)、轮廓线高度变异(G—HVC)较对侧小(P值分别为0.028、0.047),视杯形态测量(G—csu)较对侧组大(P=0.047),盘沿面积(G—RA)、盘沿体积(G—RV)与对侧组无明显差异;分区参数的S-RA、S-RV、S—MRNFLT较对侧组小(P值分别为0.033、0.01、0.008),S-CSM较对侧大(P=0.021),S-HVC与对侧无明显差别。两组在角膜厚度、屈光度、眼压、PPA的面积、范围、最大宽度方而无明显差异。将视盘面积、屈光度、G—RA、G—MRNFI。T、G—CSM、横径/纵径、B区弧度范围进行多因素吲归分析,横径/纵径为与视盘出血相关的独立因素(P=0.032,OR〈0.001:〈0.001~0.35);将视盘面积、屈光度、S-RA、S—MRNFLT、S—CSM、横径/纵径、B区弧度范围进行回归分析,横径/纵径及S-MRNFLT是与视盘出血相关的因素(S-MRNFLT:P=0.019,OR〈0.001:〈0.001~0.154;横径/纵径:P=0.02,OR〈0.001�Objective To investigate the clinical characteristics of the eyes with unilateral disc hemorrhage (DH) in normal tension glaucoma (NTG) patients. Methods 37 normal-tension glaucoma patients with unilateral DH were studied. Extensive parameters were analyzed to evaluate which parameters differ significantly between the DH eyes and the companion eyes. These parameters are: ( 1 ) intraocular pressure (IOP), (2) dioptres of refractive errors, (3) central corneal thickness (CCT) , (4) disc area, (5) disc shape including horizontal diameter, vertical diameter and horizontal diameter/vertical diameter, (6) global parameters of optic disc, including rim area( G-RA), rim volume (G-RV) , mean retinal never fiber layer thickness( G-MRNFLT), cup shape measure ( G-CSM ) and height variation contour ( G-HVC), (7) sectorial parameters of DH located area, including S-RA, S-RV, S-MRNFLT, S-CSM and S-HVC, (8) parameters of the peripapillary atrophy (PPA) beta zone including the incidence rate, area, extent and maximum width. The global and sectorial parameters of the optic disc were obtained directly from HRT- Ⅱ. The other parameters, such as optic disc horizontal diameter, vertical diameter and PPA, were obtained by processing the raw optic disc images acquired from HRT-Ⅱ using computer software lmage-pro plus version6. Univariate and multivariate regression analyses were performed on the acquired parameters. Results The disc vertical diameter (P 〈0. 01 ) and incidence rate (P =0. 031 ) of zone beta appeared to be significantly larger in the DH eyes than the ones in the contra-lateral eyes, while horizontal diameter/vertical diameter was significantly smaller in the DH eyes. As for the optic disc global parameters, the G-MRNFLT (P = 0. 028 ), G-HVC ( P = 0. 047 ) were significantly lower in the DH eyes than in the contra-lateral eyes while the G-CSM was significantly higher in DH eyes (P = 0. 047 ). The differences of G-RA, G-RV be
关 键 词:正常眼压性青光眼 视盘出血 HRT 视盘形态 视网膜神经纤维层缺损
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