微波凝固术后肝癌患者免疫功能变化的初步研究  

Immune function of patient with primary hepatocellular carcinoma after treatment of percutaneous microwave coagulation therapy

作　　者：彭齐荣[1] 肖必[1] 张健[1] 刘莉莉[1] 程涛[1] 余宙耀[1] 陈国强[2] 

机构地区：[1]中国人民解放军第458医院全军肝病中心,广东广州510602 [2]南方医科大学附属珠江医院肿瘤中心,广东广州510515

出　　处：《现代肿瘤医学》2011年第3期483-485,共3页Journal of Modern Oncology

摘　　要：目的:检测微波凝固术后肝细胞肝癌患者外周血免疫细胞指标,探讨微波凝固治疗对患者机体免疫功能的影响。方法:68例行肝癌微波凝固术治疗的患者,分别于微波凝固治疗前1天、治疗后7天、14天、21天和28天时,应用流式细胞技术检查患者外周血CD4+、CD8+、CD3+、CD4+/CD8+比值、NK细胞水平的变化。结果:微波凝固后第1周,各指标较术前无明显变化,第2周开始,CD4+值比术前明显上升,CD8+明显下降,第4周开始NK细胞水平明显升高。结论:微波凝固治疗后肝癌患者免疫功能增强,将对肝癌患者的预后起到重要作用。Objective：To study the influence of percutaneous microwave coagulation therapy（PMCT） on immunity function of patient with hepatocellular carcinoma（HCC）.Methods： Sixty eight HCC patients were treated by PMCT,the changes of CD4＋,CD8＋,CD4＋/CD8＋,NK cell by cytomatric analysis of peripheral blood were observed at day 1 before PMCT,daym 7 day 14,day 21 and 28 after PMCT.Results： At day 7,CD4＋,CD8＋,CD4＋/CD8＋,NK cell did not changed;CD4＋ increased obviously at day 14 after PMCT,while CD8＋ decreased obviously.NK cell level was increased at week 4 after PMCT.Conclusion： The immune function of patient was significantly improved in short-term after PMCT.And it played important role to prognosis of patient with liver cancer.

关 键 词：肝癌 微波凝固 免疫功能 

分 类 号：R735.7[医药卫生—肿瘤]