醛化脐带静脉管在非穿透性小梁手术治疗原发性开角型青光眼的临床研究  

Human Umbilical Vein in Non-penetrating Trabecular Surgery for Patients with Primary Open-angle Glaucoma

作　　者：李迅[1] 刘鹤南[1] 高殿文[1] 

机构地区：[1]中国医科大学附属盛京医院眼科,沈阳110004

出　　处：《中国医科大学学报》2011年第3期243-245,共3页Journal of China Medical University

基　　金：辽宁省教育厅高校科研计划项目(202013128)

摘　　要：目的评价醛化脐带静脉管（HUV）在非穿透性小梁手术（NPTS）中治疗原发性开角型青光眼（POAG）的临床疗效。方法采用前瞻性随机对照临床试验研究,对49例（49眼）POAG患者,HUV组23例行NPTS联合HUV植入,对照组26例行NPTS。术后观察、比较的指标包括：术后眼内压（IOP）、抗青光眼药物使用数量、滤过泡形态特点以及术后并发症。所有研究对象随访12个月。结果术后12个月,手术完全成功（IOP在6~21 mmHg之间,并且不需加用任何抗青光眼药物）：HUV组86.96%,对照组69.23%。术后12个月,HUV组和对照组IOP分别从术前（39.73±4.91）mmHg、（38.99±4.72）mmHg降至（15.81±1.09）mmHg、（19.88±2.21）mmHg（P=0.00）。对照组术后早期出现低眼压3例（11.54%）,HUV组未发生;对照组出现包裹性滤过泡5例（19.23%）,HUV组仅出现1例（4.35%）。结论 NPTS联合HUV植入治疗POAG,具有手术成功率高、术后IOP控制良好、术后并发症发生率低的特点。Objective To evaluate the clinical efficacy of the transplantation of human umbilical vein（HUV） in non-penetrating trabecular surgery（NPTS） for patients with primary open-angle glaucoma（POAG）.Methods A total of 49 patients（49 eyes） with POAG were included in this prospective,randomized trial.NPTS with HUV transplantation was performed in 23 eyes and NPTS without HUV in 26 eyes.The postoperative intraocular pressure（IOP）,antiglaucoma drugs,morphological characteristics of filtering blebs,and complications were compared.All the patients were followed up for 12 months.Results The complete success rate（IOP between 6 and 22 mmHg without glaucoma drugs） was 86.96% in HUV group and 69.23% in control group 12 months after the surgery.IOP decreased from 39.73±4.91 to 15.81±1.09 mmHg in HUV group and from 38.99±4.72 to 19.88±2.21 mmHg in control group 12 months after the surgery（P = 0.00）.Hypotony occurred in 3 eyes（11.54%） in control group,but did not occur in HUV group in the early postoperative stage.Filtering bleb was found in 5 eyes（19.23%） in control group and 1 eye（4.35%） in HUV group.Conclusion The combination therapy of NPTS and HUV could improve the success rate,lower the postoperative IOP,and decrease the complication rate in patients with POAG.

关 键 词：人脐带静脉管 非穿透性小梁手术 原发性开角型青光眼 

分 类 号：R775[医药卫生—眼科]