高氧液联合化疗治疗恶性肿瘤患者的临床观察  

Clinical analysis of hyperoxic solution combined with chemotherapy in the treatment of malignant tumor patients

作　　者：杨耀昆 张跃臣 王俭明 

机构地区：[1]辽宁省阜新市第二人民医院肿瘤科,辽宁阜新123000

出　　处：《中国医药导报》2011年第10期178-179,共2页China Medical Herald

摘　　要：目的:对44例恶性肿瘤患者给予高氧液联合化疗,并与只接受化疗的对照组患者进行对比分析。方法:44例恶性肿瘤患者设为治疗组,给予一线标准方案化疗,同时给予高氧液静脉输入伴随化疗每日1次。对照组患者单独采用一线标准方案化疗。2周期后观察疗效、毒副反应、KPS改善情况以及中位生存期。结果:治疗组和对照组有效率分别为23.1%和18.2%,两组比较,差异无统计学意义(P>0.05);两组中位生存期(MST)分别为31.3个月和29.8个月,两组比较,差异无统计学意义(P>0.05);治疗组和对照组的KPS改善率分别为59.6%和36.8%,两组比较,差异有统计学意义(P<0.05)。两组副性反应基本相同。结论:恶性肿瘤患者进行化疗联合静脉输注高氧液,值得临床应用。Objective：To assess the efficacy and toxicity of the combination of hyperoxic solution and chemotherapy on malignant tumour.Methods：44 malignant tumor patients were enrolled into the study.They accepted the treatment of the first standard chemotherapy and hyperoxic solution.The treatment of chemotherapy and hyperoxic solution was repeated every 21-28 days.After two cycles of chemotherapy,the efficacy and toxicity were evaluated.The other 44 patients of the comparative group were only accepted the first standard chemotherapy.Results：The efficacious rates of the two groups were 23.1%（cured group） and 18.2%（comparative group）,there was no significant difference（P〉0.05）.The median survival time（MST） of the two groups were 31.3 months and 29.8 months,there was no significant difference（P〉0.05）.The KPS improvement of the two groups were 59.6% and 36.8%,there was a significant difference（P〈0.05）.The toxicity of the two groups were almost close.Conclusion：It’s benefit from hyperoxic solution combined with chemotherapy for the malignant tumour patients.It’s worthy of promotion.

关 键 词：恶性肿瘤 高氧液 化疗 

分 类 号：R730.5[医药卫生—肿瘤]