食管上皮癌变过程的恶性肿瘤特异性生长因子测定  

Measurement of TUmor Specific Growth Factor during Carcinogenesis of Esophageal Epithelium

作　　者：张秀兰[1] 侯浚[1] 梁索元[1] 陈志峰[1] 丁镇伟[2] 王继信[2] 郭黎平[2] 刘俊宝 林培中[2] 

机构地区：[1]河北省肿瘤研究所,石家庄050011 [2]中国医学科学院中国协和医科大学肿瘤研究所,北京100021

出　　处：《基础医学与临床》1999年第4期59-61,66,共4页Basic and Clinical Medicine

摘　　要：观察食管上皮癌变过程中TSGF（恶性肿瘤特异性生长因子）的变化：验证TSGF对早期食管癌的检测能力。方法：双盲测定食管上皮癌变不同阶段人群TSGF水平；实验数据使用SAS软件拟合（GLM）过程，用最小显著差法进行分析。结果：食管上皮病变组（食管上皮重度增生、原位癌及中、晚期癌）的TSGF水平均高于正常组，（P＜0．05）。在癌变过程中，TSGF水平逐渐增高，至癌前病变达到最高值：当癌前病变发生癌变时，TSGF水平又逐渐减少。重度增生和原位癌与中、晚期癌之间亦存在显著性差异（P＜0．05）。TSGF对于食管癌的灵敏度为90．4％，对于早期食管癌的灵敏度为95．2％，对于癌前病变的灵敏度为100％；TSGF的特异度为95．0％。结论：TSGF对于检测食管癌高危人群及早期癌是一种较为灵敏的方法，值得在高发区推广应用。The authors measured double-blindly the level of TSGF in groups of persons at different stagesof carcinogenesis of esophageal epithelium. Lab results were processed with SAS packages andwere fitted to the general lineal mode (GLM) by the least significant difference. Results indicated thatTSGF levels rise gradually by the order of normal persons, persent esophagus cancer patients,cancer in situ patients, dysplasia patients. all of the latter three groups were significantly (P<0.05)higher than the normal persons; and the three groups varied significantly (P<0.05) among themselves.If 64u/mL was chosen to be the judgment point, then TSGF had a sensitivity rate of 90.4% (47/52)for esophagus cancer patients, a sensitivity rate of 95.2% (40/42) for early esophagus cancer patients and a sensitivity rate of 100% (16/16) for precancerous patients. The specificity rate of TSGFwas 95.0%. We consider TSGF to be a sensitive, accurate and reliable maker for the diagosis andearly detection of abnormal cases in high incidence areas.

关 键 词：食管癌 灵敏度 上皮癌变 TSGF 

分 类 号：R735.1[医药卫生—肿瘤]