化疗联合射频热疗治疗晚期大肠癌的临床观察  

Clinical Observation of Chemotherapy Combined with Radiofrequency Hyperthermia to Treat the Advanced Colorectal Cancer

作　　者：阮新建[1] 刘畅[1] 刘兵[1] 张侠[1] 于忠和[1] 

机构地区：[1]北京军区总医院肿瘤科,100700

出　　处：《实用癌症杂志》2011年第2期178-180,共3页The Practical Journal of Cancer

摘　　要：目的探讨化疗联合射频热疗治疗晚期大肠癌的近期疗效和不良反应。方法将符合条件的患者随机分成单纯化疗组和化疗联合射频热疗组,两组化疗方案基本相同,联合射频热疗组,同时给予射频热疗2,次/周6,0 min/次,两组治疗前后行疗效评定。结果化疗联合热疗组治疗有效率(44.11%)明显高于单纯化疗组(35.29%),但无统计学差异(P>0.05),两组主要不良反应仍是与化疗相关的副反应,如消化道反应、骨髓抑制及周围神经毒性,相比较均无统计学意义;但化疗联合射频热疗组临床受益率(58.82%)明显高于单纯化疗组(32.35%),两组差异有统计学意义(P<0.05)。结论对于晚期大肠癌患者,采用化疗联合射频热疗可获得更好的疗效和临床受益,未增加不良反应。Objective Discussion the curative effect and the side reaction of chemotherapy combined with radiofrequency hyperthermia to treat the advanced colorectal cancer.Methods Randomly divide the eligible patients into 2 groups,pure chemotherapy group and chemotherapy combined with radiofrequency hyperthermia groups.Basically,their chemotherapy project are similar.The group of Radiofrequency hyperthermia,meawhile,treat them with radiofrequency hyperthermia,twice a week,60 minutes per time.Two groups do curative effect evaluation before and after treatment.Results The effective percentage of chemotherapy combined with radiofrequency hyperthermia group（44.11%） is much higher than pure chemotherapy group（35.29%）,but it fails to have the difference（P0.05） of statistics.The side reaction of the 2 groups are still mainly related to side reaction of chemotherapy like gastrointestinal reactions,myelosuppression and peripheral nerve toxicity.To compare,it is no sense of statistics,but the clinic beifit of chemotherapy combined with radiofrequency hyperthermia groups（58.82%）is much higher than pure chemotherapy groups（32.35%）.Abviously,there is the big difference between the 2 groups and the meaning of statistcs（P0.05）.Conclusion It will have the good curative effect and？ clinic benefit to do the chemotherapy combined with radiofrequency hyperthermia for the patients suffering the advanced colorectal cancer,which does not add any side effect.

关 键 词：大肠癌 化疗联合射频热疗 

分 类 号：R735.34[医药卫生—肿瘤]