p53基因突变的霍奇金淋巴瘤R-S细胞错配修复基因蛋白的表达及意义  

Expresssion of mismatch repair genes and its significance in R-S cells of Hodgkin' s lymphoma with p53 gene mutation

作　　者：罗春英[1] 陆海善[1] 平静[1] 吴若实[1] 

机构地区：[1]右江民族医学院,广西百色533000

出　　处：《山东医药》2011年第11期18-20,共3页Shandong Medical Journal

基　　金：广西壮族自治区教育厅科研基金资助项目(200911LX337);右江民族医学院硕士启动基金资助项目(右医科字[2007]2号)

摘　　要：目的探讨错配修复基因在霍奇金淋巴瘤发生中的作用。方法采用免疫组化SP法检测霍奇金淋巴瘤标本中突变型p53蛋白及错配修复基因hMLH1、hMSH2蛋白表达情况。结果霍奇金淋巴瘤组织中R-S细胞hMSH2、hMLH1表达阳性率分别为50.00%、70.00%,未表现出错配修复基因hMSH2、hMLH1蛋白表达减低或缺失,突变型p53表达阳性率为100%。结论错配修复基因系统缺陷可能不是引发伴有p53基因突变的霍奇金淋巴瘤发生、发展的途径。Objective To investigate the significance of mismatch repair genes in the pathogenesis of Hodgkin＇ s lymphoma.Methods The protein expression of the hMLH1,hMSH2 and mutational p53 was detected by immunohistochemistry in the specimens of Hodgkin＇ s lymphoma.Results The rate of the positive protein expression of hMLH1 and hMSH2 were 50.00% and 70.00%,respectively.No diminution or absence of hMLH1and hMSH2 protein expression were found.The rate of the positive protein expression of mutational p53 was 100%.Conclusion The disfigurement of mismatch repair system may not be a approach by which Hodgkin＇ s lymphoma with p53 gene mutation occure and progress.

关 键 词：霍奇金淋巴瘤 错配修复基因 P53基因 免疫组织化学 

分 类 号：R735.2[医药卫生—肿瘤]