DNA错配修复与肺癌  

DNA Mismatch Repair and Lung Cancer

作　　者：钟智伟[1] 潘琳[1] 龙香娥[1] 乐燕萍[1] 龚朝辉[1] 

机构地区：[1]宁波大学医学院,宁波315211

出　　处：《中国细胞生物学学报》2011年第2期210-215,共6页Chinese Journal of Cell Biology

基　　金：宁波市自然科学基金(No.2009A610187)资助项目~~

摘　　要：肺癌是目前世界上最常见的恶性肿瘤之一,虽然近年来对其研究较多,但其发生发展的确切机制仍不清楚。DNA错配修复作为一种重要的复制后修复系统,在确保DNA复制保真性、控制基因突变和维持基因组稳定等方面具有重要作用。近年研究表明,DNA错配修复系统与肺癌的发生、治疗及预后判断有着密切关系。本文主要对DNA错配修复系统在肺癌中的研究进展作一简要综述。Lung cancer is one of the most common malignant tumors in the world. Although the more studies of the lung cancer are carried out in recent years, the precise mechanism of lung carcinogenesis and development remains unclear. DNA mismatch repair （MMR） is one of the important post-replication repair systems and it plays a crucial role in ensuring DNA replication fidelity, regulating gene mutation and maintaining genome stability. Recent studies demonstrate that MMR system is closely related to lung carcinogenesis, therapy and prognosis. This review mainly focuses on the progress of DNA MMR system in lung cancer.

关 键 词：DNA错配修复 微卫星不稳定 基因多态性 肺癌 

分 类 号：R734.2[医药卫生—肿瘤]