可吸收型羟基磷灰石生物陶瓷的临床应用评估  

A clinical assessment on biodegradable coral-hydroxyapatite ceramic

作　　者：何文丹[1] 陈建钢[1] 帅李娅[1] 

机构地区：[1]武汉大学中南医院口腔科,湖北武汉430071

出　　处：《临床口腔医学杂志》2011年第3期171-174,共4页Journal of Clinical Stomatology

摘　　要：目的:观察可吸收型羟基磷灰石生物陶瓷临床应用中的疗效和安全性,旨在为临床提供一种新型植骨材料。方法:60例口腔骨缺损患者分为两组:实验组植入可吸收型羟基磷灰石生物陶瓷,对照组植入牛无机骨Bio-Oss颗粒。通过术前术后对体温、血常规、血沉(ESR)、C-反应蛋白(CRP)、肝肾功能(ALT、AST、Bun、Cr),以及伤口愈合、骨愈合情况等指标的监测,对实验用植骨材料进行临床评价。结果:实验组植入材料后6个月,无1例全身性异常反应,仅1例伤口有红肿,渗液,3周内伤口愈合。骨愈合情况:植入区的骨密度增高,骨愈合良好,实验组与对照组无明显差异。结论:可吸收型羟基磷灰石可用于拔牙创及牙种植周围骨缺损修复,该材料无不良反应,无毒副作用,能加速骨缺损的修复。Objective：To investigate the efficacy and safety of the Biodegradable Coral-hydroxyapatite Ceramic （BCHA） in clinical application.Method：60 cases of Oral bone defects were divided into 2 groups,BCHA and inorganic bovine bone Bio-Oss particles were applied to the A（experimental group） and B group（control group）.By compared with preoperative and postoperative changes of body temperature,blood count,erythrocyte sedimentation rate （ESR）,C-reactive protein（CRP）,liver and kidney function（ALT,AST,Bun,Cr）,and wound healing,bone healing,clinical efficacy and safety were evalued.Result：6 months followed up,no abnormal systemic reactions,only 1 case of wound swelling,exudate,and the others healed within 3 weeks.Bone healing as follows：Experimental group and control group have no significant difference in bonemineral density increased and bone healed well.Conclusion：The BCHA can be used in tooth extraction wounds and bone defects around dental implants,no adverse reactions to the material,non-toxic side effects were found.It can accelerate the repair of bone defects.

关 键 词：骨缺损 可吸收型羟基磷灰石 疗效性 安全性 

分 类 号：R782.2[医药卫生—口腔医学]