Hedgehog信号通路与肿瘤侵袭转移作用的研究进展  

Advances in the research of Hedgehog signaling pathway associated with the invasion and metastasis of tumors

作　　者：欧阳小波[1] 王立[1] 

机构地区：[1]重庆医科大学附属第一医院消化内科,重庆400016

出　　处：《肿瘤》2011年第2期173-177,共5页Tumor

摘　　要：Hedgehog家族蛋白是胚胎发育中的重要形态发生素,Hedgehog信号通路的不恰当地激活可引起多种肿瘤的发生。近年来,有关Hedgehog信号通路的研究取得了较大的进展,对其在肿瘤的发生、发展中的作用有了新的认识。有证据显示,Hedgehog信号通路参与肿瘤的侵袭和转移。本文就Hedgehog信号通路促进肿瘤侵袭转移、分子调控和可能参与的信号途径作一系统的综述,以期为潜在依赖Hedgehog信号通路的肿瘤治疗策略提供一些新的思路。Hedgehog family proteins are important morphogens which mediate the development of embryo as well as the carcinogenesis in adults.Inappropriate activation of Hedgehog signaling pathway contributes to numerous human cancers.The Hedgehog signaling pathway is considered to be involved in the molecular mechanism of the invasion and metastasis of the tumors,and to facilitate the metastasis of tumors through signaling pathways interaction.It is suggested that a potential therapeutic strategy pharmacologically targeting Hedgehog-dependent tumors may be developed.

关 键 词：肿瘤 信号转导 肿瘤侵润 肿瘤转移 HEDGEHOG信号通路 

分 类 号：R73-37[医药卫生—肿瘤]