尼莫地平联合阿托伐他汀治疗血管性认知障碍的疗效观察  

The efficacy of combiration therapy with nimodipine cand atorvastatin for the patients with vascular cognitive impairment

作　　者：龙建庭[1] 鲁玲[1] 成明强[1] 彭琼[1] 游咏[1] 

机构地区：[1]南华大学附属第一医院神经内科,421001

出　　处：《卒中与神经疾病》2011年第1期23-26,共4页Stroke and Nervous Diseases

基　　金：湖南省卫生厅医药卫生科研计划课题(B2006-112);湖南省卫生厅科研计划课题(B2010-044);南华大学研究生创新课题(2010XCX14)

摘　　要：目的探讨尼莫地平联合阿托伐他汀治疗血管性认知障碍的临床疗效及其不良反应。方法将96例血管性认知障碍患者随机分为对照组和治疗组,每组48例,再根据神经心理学评分将每组分为VCIND和VaD两个亚组。对照组给予了常规治疗+安慰剂治疗,治疗组予尼莫地平+阿托伐他汀治疗,尼莫地平30mg/d,1日3次,阿托伐他汀20mg/d,晚上1次,疗程均为6个月。采用MoCA和ADL评分对患者进行神经心理学评分。结果与同组治疗前相比,治疗组治疗6个月后MoCA和ADL评分分值明显提高(P<0.01);与对照组相比,治疗组治疗后MoCA和ADL评分值提高(P<0.05)。对照组中VCIND患者MoCA和ADL较治疗前降低(P<0.05);治疗组中VCIND患者较治疗前及对照组MoCA和ADL分值明显提高(P<0.01),VaD患者无明显提高(P>0.05)。2组均未见严重的不良反应。结论尼莫地平联合阿托伐他汀治疗血管性认知障碍的临床疗效较好,不良反应少。Objective To observe the efficacy and safety of the combination therapy with nimodipine and atorvastatin for patients with vascular cognitive impairment（VCI）.Methods Ninety-six patients with VCI were devided rardomizedly into intervention group,receiving nimodipin（90 mg/d） and atorvastatin（20 mg/d）,and to control group,receiving placebno.Forty-eight participants were in each group.The sub-group of vascular cognitive impairment without dementia（VCIND） and vascular dementia（VaD） in intervention and control group were devided according to the score of neuropsychological test.The duration of treatment was 6 months.The efficacy was evaluated by using Montreal Cognitive Assessment （MoCA） and activities of daily living（ADL） before and after treatment.Results There was significant difference in the score of MoCA and ADL between the two groups after treatment（P0.05）.After treatment for six months,the score of MoCA and ADL were increased significantly in the intervention group compared with that before teatment （P0.01）.The score in the the VCIND group of the control group was also decreased more obviously than it that before teatment （P0.05）.The score in the the VCIND group of the intervention group was increased sharply than that in the control group and that before treatment（P0.01）.However,there were no statistical significance in the VaD group of the intervention group （P0.05）.There were no serious adverse reaction in two groups.Conclusions The combiration therapy with nimodipine and atorvastatin has positive effect for patients with vascular cognitive impairment.No serious adverse events occured during the experment.

关 键 词：尼莫地平 阿托伐他汀 血管性认知障碍 

分 类 号：R749.13[医药卫生—神经病学与精神病学]