眼附属器恶性淋巴瘤172例临床病理分析  

Clinical and pathological analysis of 172 cases with malignant ocular adnexal lymphoma

作　　者：徐玲[1] 蒋永强[1] 吴晓梅[1] 罗清礼[1] 夏瑞南[1] 

机构地区：[1]四川大学华西医院眼科,四川省成都市610041

出　　处：《眼科新进展》2011年第3期254-257,共4页Recent Advances in Ophthalmology

摘　　要：目的初步探讨眼附属器恶性淋巴瘤的临床特点及病理学分类。方法 对172例187眼经组织病理学确诊的眼附属器恶性淋巴瘤患者的临床及病理资料进行回顾性分析。结果 患者年龄12～85岁,平均63岁,病程13d～25a,平均75个月。其中眼眶恶性淋巴瘤最多见,共98眼(52.33%),其次为结膜48眼(25.00%)及眼睑37眼(20.35%)、泪囊4眼(2.33%)。免疫组织化学染色146例159眼(84.88%)均为非霍奇金淋巴瘤,其中86例95眼(58.90%)确诊为低度恶性黏膜相关淋巴组织淋巴瘤(MALT淋巴瘤)。眼附属器恶性淋巴瘤以眼睑色块和结膜新生物128眼(69.77%)或眼球突出48眼(25.00%)为主要就诊原因。结论 眼附属器恶性淋巴瘤多为黏膜相关性淋巴组织淋巴瘤,免疫组织化学检测有助于诊断。准确的肿瘤病理学分类不仅能指导临床治疗,还能反映患者预后。Objective To initial investigate the pathological classification and clinical features of malignant ocular adnexal lymphoma.Methods The clinical and pathologic information of 172 cases with malignant ocular adnexal lymphoma,who were final diagnosed by histopathology,were analyzed retrospectively.Results The patients ages averaged at 63 years old（from 12 years old to 85 years old）.The mean course of disease was 75 months（from 13 days to 25 years）.Classification by anatomic sites：orbit 98 eyes（52.33%）,conjunctiva 48 eyes（25.00%）,eyelid 37 eyes（20.35%）.The immunohistochemistry staining in 146 cases（159 eyes） with non-Hodgkin lymphomas,among which 86 cases were MALT-malignant lymphoma.Neoplasm of eye（128 eyes,69.77%） or exophthalmos（48 eyes,25.00%） was the major manifestation and main reason for ophthalmic examination.Conclusion MALT-malignant lymphoma is the most frequent type of malignant lymphoma in ocular adnexa.Immunohistochemistry is helpful in the diagnosis.Accurate pathological classification can guide therapy and estimate prognosis.

关 键 词：眼附属器 恶性淋巴瘤 临床特点 病理分类 

分 类 号：R777[医药卫生—眼科]