非致死剂量超声对卵巢癌细胞超微结构的影响  

Effects of Ultrasound of Nonlethal Dosage on Ultrastructure of Human Ovarian Carcinoma Cell Line 3AO in vitro

作　　者：于廷和[1] 王国云[1] 蔡汉钟[2] 王智彪[2] 

机构地区：[1]济南市山东医科大学附属医院 [2]重庆市重庆医科大学医学超声工程研究所

出　　处：《中国超声医学杂志》1999年第9期647-648,共2页Chinese Journal of Ultrasound in Medicine

基　　金：九五国家重点攻关项目资助

摘　　要：目的⑶研究非致死剂量超声对体外培养的人卵巢癌细胞超微结构的影响⒚方法⑶卵巢癌细胞 ３ Ａ Ｏ 受非致死剂量超声辐照后⒙观察其超微结构的变化⒚结果⑶大部分受辐照细胞形态学变化不明显⒚部分细胞线粒体肿胀、嵴断裂。Objective:To determine the effects of nonlethal dosage ultrasound on ultrastructure of human ovarian carcinoma cell line 3AO in vitro.Methods:3AO cells were exposed to nonlethal ultrasound.Their ultrastructure alterations were inspected and compared with cells sham irradiated.Results:No significant ultrastructure alterations in most cells were observed,although swollen mitochondria,fractured ridge,even ruptured membrane and cytoplasmic cavitations appeared in some irradiated cells.Conclusion:Nonlethal dosage ultrasound could lead mitochondria damage to ovarian carcinoma by cells cavitation.

关 键 词：卵巢癌 癌细胞 超微结构 超声波疗法 

分 类 号：R737.310.5[医药卫生—肿瘤] R454.3[医药卫生—临床医学]