胃癌组织中黏附分子整合素CD11c的表达及其与预后的关系  

Expression and clinical significance of adhesion molecule CDllc in gastric carcinoma

作　　者：胡文蔚[1] 蒋敬庭[1] 吴昌平[1] 

机构地区：[1]江苏省苏州大学附属第三医院肿瘤生物诊疗中心,常州 213003

出　　处：《中华实验外科杂志》2011年第4期567-570,F0003,共5页Chinese Journal of Experimental Surgery

基　　金：基金项目：国家自然科学基金资助项目（30950022、30972703）;江苏省卫生厅医学科技发展基金资助项目（P200932、P200933）;江苏省卫生厅“科教兴卫工程”开放课题基金资助项目（KF200972）;常州市社会发展计划资助项目（CS20092019）

摘　　要：目的探讨黏附分子家族的成员CD11C在胃癌组织中的表达及其与预后的关系。方法采用免疫组织化学染色法检测125例胃癌患者癌组织CD11c的表达。结果CD11c在胃癌中的表达高于胃炎和胃息肉组织。CD11c与患者性别、年龄、病理分级、胃癌部位无关（P〉0．05）；与肿瘤大小、浸润深度、淋巴结转移、组织类型、复发和TNM分期明显相关。肿瘤直径〈5cm组CD11c的表达水平（12．4±6．8）高于肿瘤直径≥5cm组（7．7±4．6），差异有统计学意义（t=3．98，P〈0．01）。浸润深度与CD11C表达水平显著关联，未侵入肌层组胃癌的CDllC表达水平（15．4±8．5）显著高于侵入肌层组（9．5±5．6），差异有统计学意义（t=3．1，P〈0．05）。淋巴结转移与CDlle表达水平显著关联，未有淋巴结转移的CD11c表达水平（15．3±6．6）显著高于淋巴结转移组（8．6±5．1），差异有统计学意义（t=5．44，P〈0．01）。未复发组的CDlle表达水平（12．3±7．4）高于复发组（9．0±5．3），差异有统计学意义（t=2．90，P〈0．01）。分化型组的CD11c表达水平（9．3±5．3）低于低分化型组（12．6±7．8），差异有统计学意义（t=2．68，P〈0．01）。CDllC表达随肿瘤临床分期的递增而降低，各组间差异有统计学意义（P〈0．01）。多因素COX模型分析，在调整了性别、年龄、肿瘤大小、是否侵及深肌层、分化程度后，与CD11c细胞低表达组比较，高表达组有降低胃癌死亡风险的趋势（RR=0．51，95％CI=0．22～1．16）。结论CD11c表达与胃癌预后有关，可以作为反映患者免疫状态和预后的指标之一。Objective To investigate the expression of CDllc in gastric carcinoma and the clinical significance. Methods The expression of CDllc in gastric carcinoma, gastritis tissue and gastric pol- yp was detected by using immunohistochemical assay. Results The expression level of CDlle in gastric carcinoma was higher than that in gastritis tissue and gastric polyp. There was no significant difference in the CD11c expression among gender, age, pathological grade, primary area （P 〉 0. 05 ）. There was signif- icant difference in the CD11c expression among tumor size, invasive depth, lymph node metastasis, histological type, recurrence and clinical stage. The expression of CD11 c in tumor size 〈 5 cm group （ 12.4 ± 6. 8 ） was higher than that in tumor size ≥5 cm group （7.7 ± 4.6） , （ t = 3.98,P 〈 0. 01 ）. The expression of CD11 c in non-invasion group （ 15.4 ± 8.5 ） was obviously higher than that in invasion group （ 9. 5 ± 5.6）, （t =3.1 ,P 〈0. 05）. The expression of CDllc in non-lymph node metastasis group （15.3 ±6. 6） was obviously higher than that in lymph node metastasis group （ 8.6 ± 5.1 ） , （ t = 5.44 ,P 〈 0. 01 ）. The expression of CD11 c in non-recurrence group （12. 3 ± 7.4） was higher than that in recurrence group （9. 0 ± 5.3 ）, （t = 2. 90 ,P 〈 0. 01 ）. The expression of CD11 c in differentiation group （9.3 ± 5.3 ） was lower than that in low differentiation group （ 12. 6 ±7.8） , （t =2. 68 ,P 〈0. 01 ）. There was significant diference among groups of clinical stage （ P 〈 0. 01 ）. The multivariate Cox analysis revealed that the risk of death in high expression group was significantly lower than that in low expression group （ RR = 0. 51, 95% CI = 0. 22-1.16）. Conclusion Detection of the CDlle expression in gastric carcinoma is beneficial to the jud±rnent of the prognosis of gastric carcinoma and the choice of individualized treatment.

关 键 词：胃癌 CD11C 黏附分子 免疫组织化学 

分 类 号：R735.2[医药卫生—肿瘤]