柴胡龙牡汤对精神分裂症大鼠模型刻板行为和胶质细胞纤维酸性蛋白(GFAP)表达的影响  

LONGMU BUPLEURUM DECOCTION ON STEREOTYPED BEHAVIOR AND EXPRESSION OF GLIAL FIBRILLARY ACIDIC PROTEIN (GFAP) IN RAT MODEL OF SCHIZOPHRENIA

作　　者：李东阳[1] 周秀芳[1] 孙晓东[1] 陈涛[1] 鲁娜[1] 

机构地区：[1]贵阳中医学院医学人文系,贵阳550002

出　　处：《现代预防医学》2011年第7期1296-1297,共2页Modern Preventive Medicine

摘　　要：[目的]观察柴胡龙牡汤对精神分裂症大鼠模型刻板行为和GFAP表达的影响。[方法]将44只大鼠分为4组,空白组腹腔注射生理盐水。剩余3组均用氯胺酮造模(腹腔注射氯胺),其中氯氮平组从d4开始加用氯氮平灌胃,柴胡龙牡汤组从d4开始加用柴胡龙牡汤灌胃。[结果]模型组刻板行为较空白组明显增多;氯氮平组和柴胡龙牡汤组刻板行为均较模型组明显减少;柴胡龙牡汤组刻板行为较氯氮平组增多。模型组GFAP表达较空白组明显增多;氯氮平组GFAP表达较模型组明显减少;柴胡龙牡汤组GFAP表达较模型组明显减少;柴胡龙牡汤组GFAP表达较氯氮平组增多。[结论]柴胡龙牡汤对精神分裂症大鼠模型前额叶GFAP和刻板行为有一定的影响。[Objective]To observe Longmu Bupleurum Decoction on stereotyped behavior and GFAP expression in rat model of schizophrenia.[Methods]44 rats were divided into 4 groups,control group injected with normal saline.The remaining three groups were made using ketamine model（intraperitoneal injection of ketamine）,in which clozapine group was added intragastric administration of clozapine from the fourth day,Chai Hu Tang Longmu d starting was added intragastric administration of Bupleurum Longmu from the fourth day.[Results]The stereotyped behavior in model group increased significantly comparing with control group;the stereotyped behaviors in clozapine group and Bupleurum Decoction group Longmu were significantly reduced comparing with model group;the stereotypic behavior in Bupleurum Longmu Decoction increased more comparing with that in clozapine group.GFAP expression in model group increased significantly comparing with control group;GFAP expression in clozapine group was significantly reduced comparingwith the model;GFAP expression in Bupleurum Decoction Longmu was significantly reduced comparing with the model;GFAP expression in Bupleurum Longmu Decoction increased more comparing with clozapine group.[Conclusion]Bupleurum Longmu Decoction has effect on prefrontal cortex GFAP and stereotyped behavior of rat model of schizophrenia to a certain extent.

关 键 词：柴胡龙牡汤 氯氮平 精神分裂症模型 刻板行为 GFAP 

分 类 号：R749.3[医药卫生—神经病学与精神病学]