小剂量尿激酶对短暂性脑缺血发作患者多项血清因子水平影响研究  

EFFECT OF LOW DOSE OF UROKINASE ON SERUM FACTORS OF PATIENTS WITH TRANSIENT ISCHEMIC ATTACK

作　　者：黄妍[1] 吴郁珍[1] 胡雨云[1] 王金高[1] 俞祥玫[1] 

机构地区：[1]厦门大学附属第一医院急诊内科,厦门3651003

出　　处：《现代预防医学》2011年第7期1368-1369,共2页Modern Preventive Medicine

摘　　要：[目的]探讨小剂量尿激酶对短暂性脑缺血发作患者多项血清因子水平的影响。[方法]选取2007年10月~2010年10月于某院进行治疗的78例短暂性脑缺血发作患者为研究对象,将其随机分为对照组（常规治疗组）39例和观察组（加用尿激酶组）39例,观察两组的临床效果及治疗后3d和7d血清DD、IL-6、IL-8和TNF-α水平。[结果]观察组的临床效果优于对照组,治疗后观察组的血清DD在3d优于对照组（P﹤0.05）、在IL-6、IL-8和TNF-α上,3d和7d均优于对照组（P﹤0.05）。[结论]小剂量尿激酶对改善短暂性脑缺血发作,患者血清DD、IL-6、IL-8和TNF-α水平控制较好,值得临床推广应用。[Objective]To explore the impact of low dose of urokinase on serum factors of patients with transient ischemic attacks.[Methods]Selected 78 transient ischemic attack patients for treatment in our hospital from October 2007-October 2010,then randomly divided into control group（conventional treatment group）39 cases and the observation group（added with the urine kinase group）39 cases,and the observed clinical effects,serum DD,IL-6,IL-8 and TNF-α levels in two groups after 3d-and 7d treatment.[Results]The clinical effect of the observation group was better than the control group,after 3d-treatment,the serum DD in observation group was better than the control group（P﹤0.05）,the IL-6,IL-8 and TNF-α after 3d-and 7d-treatment were superior to control group（P﹤0.05）.[Conclusion]Small dose of urokinase could improve transient ischemic attack,control patients＇ DD,IL-6,IL-8 and TNF-α levels better,which is worthy of clinical application.

关 键 词：短暂性脑缺血发作 D-二聚体 白细胞介素-6 白细胞介素-8 肿瘤坏死因子-α 

分 类 号：R743.31[医药卫生—神经病学与精神病学]