^131I治疗青少年Graves病58例临床分析  

Analyze of^131I therapy on 58 youngsters with Graves＇ disease

作　　者：牟联超 李先映[1] 石彩虹[2] 

机构地区：[1]湖北省天门市第三人民医院核医学科,431700 [2]湖北省天门市第三人民医院超声科,431700

出　　处：《国际放射医学核医学杂志》2010年第5期299-301,共3页International Journal of Radiation Medicine and Nuclear Medicine

摘　　要：目的研究^131I治疗青少年Graves病的可行性和安全性。方法回顾性分析58例经^131I治疗的青少年Graves病患者，分别于^131I（剂量：148—240．5MBq）治疗前和治疗6个月后，用化学发光免疫法检测血清游离三碘甲腺原氨酸（FT3）、游离甲状腺素（FT4）、促甲状腺激素（TSH）水平及用彩色多普勒超声测量甲状腺大小；随访2—7年，评价疗效。结果治疗6个月后，血清订，和FT4水平明显降低（t=12．43，t=21．21，P均〈0．01），TSH水平明显升高（t=-10．34，P〈0．01），甲状腺体积明显缩小。58例患者中，治愈31例（53．45％），好转16例（27．59％），无效7例（12．07％），甲减3例（5．17％），复发1例（1．72％）。结论^131I治疗青少年Graves病安全有效。Objective To study the feasibility and curative effect of ^131Itherapy for youngsters with Graves＇ disease. Methods Retrospective analyzed 58 youngsters with Graves＇ disease, to compare the serum free triiodthyroine （FT3）, free thyroxine （FT4） and thyroid-stimulating hormone （TSH）levels with chemiluminescent immunoassay and to measure the thyroid gland size with color Doppler diagnostic apparatus before and after six months of ^131I（148-240.5 MBq） therapy, then followed up for 2-7 years, and clinical efficacy was evaluated according to the results. Results After 6 months of therapy, the levels of ^131I and FTg were significantly decreased（t=12.43, t=21.21, P〈0.01）, the level of TSH was significantly increased （t=10.34, P〈0.01）, and thyroid volume was decreased obviously. Of the 58 patients, 31 （53.45%）patients were cured, 16 （27.59%） were much better than before, and 7 （12.1%） were invalid, 3 （5.17%） were temporary hypothyroid, 1 （1.72%） recrudesced. Conclusion ^131Iis an effective therapy which is safe and economical to youngsters with Graves＇ disease.

关 键 词：格雷夫斯病 碘放射性同位素 近距离放射疗法 青少年 

分 类 号：R581.1[医药卫生—内分泌]