正电子放射性显像剂^18F—FDG的研究进展  

The progress of reserch on positron radioactive ^18F-FDG

作　　者：孙华[1] 杨雁[2] 李琳[1] 杨发科[1] 赵雷[1] 

机构地区：[1]昆明医学院第三附属医院云南省肿瘤医院PET/CT中心,650018 [2]昆明医学院第三附属医院云南省肿瘤医院药剂科,650018

出　　处：《国际放射医学核医学杂志》2010年第6期333-336,362,共5页International Journal of Radiation Medicine and Nuclear Medicine

摘　　要：^18F—FDG是PET-CT影像诊断重要的示踪剂之一，采用亲核取代反应制备^18F-FDG比亲电取代反应更优越，因此，前者取代后者将势在必行。全自动合成模块工艺对放射性药物的规模化生产以及临床上的广泛应用起到了推动作用。近年来，新技术手段在^18F-FDG合成模块中的应用也引起了人们的广泛关注。作为以静脉注射方式给药的示踪剂，^18F—FDG的质量控制要求严格。先进的检测手段以及药品生产和质量管理规范的实施为^18F—FDG的质量控制提供了保证。对^18F—FDG的代谢动力学研究发现，该示踪剂静脉注射后的代谢过程符合三室模型，为临床用药提供了依据。该文从合成原理、工艺流程、质量控制、代谢分布与临床应用等几个方面对^18F—FDG的研究进展进行综述。As one of the most important tracer for PET-CT, the preparation of ^18F-FDG by nucleophilie substitution is better than electrophilie substitution,therefore the substitution of the former for the latter is imperative. Automatic synthesis module technology has powerful function on the large-scale production of radioactive drugs and widely clinical been used. In recent years the application of new technology in ^18F-FDG synthesis module is very fascinating. The requirement for quality control of ^18F-FDG is tremendously strict, for which the administration way of ^18F-FDG is intravenous injection. The advanced detective methods and the standardization of Good Manufacturing Practice are guarantee to ^18F-FDG quality control. The researches on pharmacokinetics of ^18F-FDG show that the metabolic process accords with three-compartment model after in- travenous, which provides a basis for clinical medication. In this paper, we review the ^18F-FDG in detail from the principle of synthesis, craft process, quality control, metabolic distribution and clinical application and so on.

关 键 词：氟脱氧葡萄糖F18 质量控制 药代动力学 工艺学 制药 

分 类 号：R9[医药卫生—药学]