鼻咽癌组织中COX-2表达与树突状细胞浸润的相关性研究  

The Relationship Between the Expression of COX-2 in Nasopharyngeal Carcinoma Tissues and the Dendritic Cells Infiltration

作　　者：张静渊[1] 徐新宇[1] 何侠[1] 张彤[1] 

机构地区：[1]江苏省肿瘤医院病理科,江苏南京210009

出　　处：《肿瘤基础与临床》2011年第1期10-12,共3页journal of basic and clinical oncology

摘　　要：目的探讨环氧化酶-2(COX-2)在鼻咽癌(NPC)组织中的表达及其与树突状细胞(DCs)浸润的关系。方法采用免疫组化S-P法检测32例NPC组织中COX-2表达及其与DCs浸润程度的关系。结果 COX-2在NPC组织中的阳性表达率为87.5%,正常鼻咽黏膜组织中的阳性表达率为6.25%,差异有统计学意义(P<0.05)。COX-2在NPC组织中的表达与淋巴结转移有关(P<0.05),而与NPC患者的年龄、肿瘤大小、受累程度和肿瘤的分化程度无关(P>0.05)。淋巴结转移NPC患者DCs的浸润数量明显低于无淋巴结转移者,差异有统计学意义(P<0.05)。DCs低浸润组COX-2阳性表达率为93.33%,DCs高浸润组COX-2阳性表达率为82.35%,差异有统计学意义(P<0.05)。结论 NPC组织中COX-2的表达和DCs的浸润程度共同影响着NPC的预后,并且两者之间有一定的关联性。Objective To investigate the relationship between the expressions of cyclooxygenase-2 （COX-2） in nasopharyngeal carcinoma （NPC） and the dendritic cells （DCs） infiltration. Methods The expressions of COX-2 were detected by immunohistochemiscal S-P method in 32 patients with NPC, and its relationship to DCs infiltration was analyzed. Results The expression rate of COX-2 was 87.5% in the NPC, which was significantly higher than that in the normal nasopharyngcal mucosa（ P 〈 0.05 ）. The expressions of COX-2 were highly corre- lated to lymphnode metastasis; and were not related to the age of patients, the tumor size,the tumor differentiation and the extent of tumor in- volvement（ P 〉 0.05 ）. The average number of DCs invasion accompanied with lymphnode metastasis was lower than that of patients without lymphnode metastasis （ P 〈 0.05 ）. The positive expression rate of COX-2 was 93.33 % in the low infiltration DCs group,82.35% in the high infiltration group（ P 〈 0.05 ）. Conclusion The expressions of COX-2 and the infiltration of DCs significantly affect the prognosis of NPC, and there was a certain correlation between the two factors.

关 键 词：鼻咽癌 环氧化酶-2 树突状细胞 免疫组织化学 

分 类 号：R739.63[医药卫生—肿瘤] R730.23[医药卫生—临床医学]