门静脉泵灌注化疗预防肝癌术后复发的作用  

The Preventive Effect of Portal Vein Chemotherapy on Postoperative Recurrence of Hepatocellular Carcinoma

作　　者：石好岭[1] 庞志刚[1] 尚闯[1] 

机构地区：[1]郑州大学第二附属医院,河南郑州450003

出　　处：《肿瘤基础与临床》2011年第1期23-24,共2页journal of basic and clinical oncology

摘　　要：目的探讨门静脉泵灌注化疗对肝癌根治术后复发的预防作用。方法 193例肝癌患者行根治术后随机分为门静脉置泵组和对照组。门静脉置泵组行灌注化疗1年。两组分别追踪观察其术后复发情况。结果门静脉置泵组术后1、2、3年复发率分别为10.9%、38.1%、51.7%,明显低于对照组的19.6%、47.8%、76.1%(P<0.01)。同时门静脉泵灌注化疗能明显提高肝癌根治术后患者的生存率(P<0.01)。结论门静脉泵灌注化疗能有效降低肝癌术后复发率,并延长术后患者的生存期。Objective To explore the preventive effect of portal vein chemotherapy on the recurrence after radical resection of hepatocellular carcinoma. Methods All the 193 patients with hepatocellular carcinoma who underwent radical resection were randomly divided into two groups：the 147 patients underwent prophylactic portal vein chemotherapy after operation, and the 46 patients underwent radical resection. The 147 patients in the portal vein chemotherapy group received chemotherapy for 1 year. The recurrence of all the patients were observed. Results The 1-,2- and 3-year recurrence rate was 10.9% ,38.1% and 51.7% in the portal vein chemotherapy group; and 19.6% ,47.8%, 76.1% in the control group （P 〈 0.01 ）. The survival rates of the portal vein chemotherapy group was significantly higher than those of the control group （P 〈 0.01 ）. Conclusion Portal vein chemotherapy after radical resection can decrease the postoperative recurrence rate of hepatocellular carcinoma, and prolong the survival time.

关 键 词：肝癌 根治性切除 门静脉化疗 复发 

分 类 号：R730.53[医药卫生—肿瘤] R735.7[医药卫生—临床医学]