利用组织芯片检测水通道蛋白1在乳腺癌组织中的表达  

Using tissue microarray detect the expression of AQP1 in breast carcinoma

作　　者：王楠[1] 肖英红[1] 王宇[1] 冯学超[1] 何成彦[2] 

机构地区：[1]东北师范大学膜通道实验室,吉林长春130024 [2]吉林大学中日联谊医院,吉林长春130033

出　　处：《中国实验诊断学》2011年第3期402-403,共2页Chinese Journal of Laboratory Diagnosis

基　　金：国家自然科学基金资助项目(30770493)

摘　　要：目的检测水通道蛋白1(AQP1)在乳腺癌组织中的表达及临床意义。方法购买含有32对乳腺癌组织标本及癌旁正常乳腺组织标本的组织芯片,应用免疫组织化学方法检测AQP1的表达。结果乳腺癌组织和癌旁正常乳腺组织中AQP1的平均表达率分别为70.56±14.71%、18.64±8.54%,二者存在显著差异(P<0.05)。结论 AQP1在乳腺癌组织中表达增高,AQP1可能与乳腺癌生长、转移有关。Objective to explore the expression of aquaporin-1（AQP1） in breast cancer tissue and its clinical significance.Methods a tissue microarray containing 32 cases of breast cancer tissues and non-cancerous adjacent tissues was assessed immunohistochemistry to detect expression of AQP1.Results the expression rate of AQP1 in cancerous group was 70.56±14.71%,and that in normal group was 18.64±8.54%;there was significantly difference between the two groups（P0.05）.Conclusion the expression of AQP1 in breast cancer tissue is remarkably higher than non-cancerous breast tissue.It suggests that AQP1 may be related to the growth and metastasis of breast cancer.

关 键 词：乳腺肿瘤 AQP1 肿瘤转移 

分 类 号：R737.9[医药卫生—肿瘤]